Caffo, M.; Curcio, A.; Rajiv, K.; Caruso, G.; Venza, M.; Germanò, A. Potential Role of Carbon Nanomaterials in the Treatment of Malignant Brain Gliomas. Cancers 2023, 15, 2575, doi:10.3390/cancers15092575.
Caffo, M.; Curcio, A.; Rajiv, K.; Caruso, G.; Venza, M.; Germanò, A. Potential Role of Carbon Nanomaterials in the Treatment of Malignant Brain Gliomas. Cancers 2023, 15, 2575, doi:10.3390/cancers15092575.
Caffo, M.; Curcio, A.; Rajiv, K.; Caruso, G.; Venza, M.; Germanò, A. Potential Role of Carbon Nanomaterials in the Treatment of Malignant Brain Gliomas. Cancers 2023, 15, 2575, doi:10.3390/cancers15092575.
Caffo, M.; Curcio, A.; Rajiv, K.; Caruso, G.; Venza, M.; Germanò, A. Potential Role of Carbon Nanomaterials in the Treatment of Malignant Brain Gliomas. Cancers 2023, 15, 2575, doi:10.3390/cancers15092575.
Abstract
Malignant gliomas are the most common primary brain tumors in adults up to an extent of 78% of all primary malignant brain tumors. However, total surgical resection is almost unachievable due to considerable infiltrative ability of glial cells. The efficacy of current multimodal therapeutic strategies is, furthermore, limited by the lack of specific therapies against malignant cells, and, therefore, the prognosis these in patients is still very unfavorable. The limitation of conventional therapies, which may result from inefficient delivery of the therapeutic or contrast agent to brain tumors are major reasons for this unsolved clinical problem. The major problem in brain drug delivery is the presence of the blood brain barrier which limits the delivery of many chemotherapeutic agents. Nanoparticles, thanks to their chemical configuration, are able to go through the blood-brain barrier carrying drugs or genes targeted against gliomas. Carbon nanomaterials show distinct properties including electronic properties, penetrating capability on the cell membrane, high drug-loading and pH-dependent therapeutic unloading capacities, thermal properties, large surface area and easy modification with molecules, which render them as a suitable candidate to deliver drugs. In this review we will focus on the potential effectiveness of the use of carbon nanomaterials in the treatment of malignant gliomas discussing the current progress of in vitro and in vivo researches of carbon nanomaterials-based drug delivery to brain.
Medicine and Pharmacology, Oncology and Oncogenics
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