PreprintReviewVersion 1Preserved in Portico This version is not peer-reviewed
Direct Implications between Prenatal Alcohol Consumption and Gut Microbiome in the Neurodevelopment of Mice Offspring – Focusing On Foetal Alcoholic Spectrum Disorders
Version 1
: Received: 9 December 2022 / Approved: 12 December 2022 / Online: 12 December 2022 (13:50:01 CET)
How to cite:
Pedroso-Roussado, C.; Guppy, F.; Bowler, L.; Inacio, J. Direct Implications between Prenatal Alcohol Consumption and Gut Microbiome in the Neurodevelopment of Mice Offspring – Focusing On Foetal Alcoholic Spectrum Disorders. Preprints2022, 2022120205. https://doi.org/10.20944/preprints202212.0205.v1
Pedroso-Roussado, C.; Guppy, F.; Bowler, L.; Inacio, J. Direct Implications between Prenatal Alcohol Consumption and Gut Microbiome in the Neurodevelopment of Mice Offspring – Focusing On Foetal Alcoholic Spectrum Disorders. Preprints 2022, 2022120205. https://doi.org/10.20944/preprints202212.0205.v1
Pedroso-Roussado, C.; Guppy, F.; Bowler, L.; Inacio, J. Direct Implications between Prenatal Alcohol Consumption and Gut Microbiome in the Neurodevelopment of Mice Offspring – Focusing On Foetal Alcoholic Spectrum Disorders. Preprints2022, 2022120205. https://doi.org/10.20944/preprints202212.0205.v1
APA Style
Pedroso-Roussado, C., Guppy, F., Bowler, L., & Inacio, J. (2022). Direct Implications between Prenatal Alcohol Consumption and Gut Microbiome in the Neurodevelopment of Mice Offspring – Focusing On Foetal Alcoholic Spectrum Disorders. Preprints. https://doi.org/10.20944/preprints202212.0205.v1
Chicago/Turabian Style
Pedroso-Roussado, C., Lucas Bowler and Joao Inacio. 2022 "Direct Implications between Prenatal Alcohol Consumption and Gut Microbiome in the Neurodevelopment of Mice Offspring – Focusing On Foetal Alcoholic Spectrum Disorders" Preprints. https://doi.org/10.20944/preprints202212.0205.v1
Abstract
Disorders associated with substance abuse are a major public health crisis with few treatment options. According to World Health Organization (WHO) ethanol is the most widely used drug in the world, and it represents a risk factor for the advent of disease, disability, and eventually death. Foetal Alcoholic Spectrum Disorders (FASD) is a diagnostic term to describe the range of effects that can occur in an individual whose mother drank alcohol during pregnancy. These effects encompass both physical, mental, behavioural and further lifelong disabilities. Besides, ethanol can harm the gut microbiota. Gut microbiome is firstly acquired from the mother and it is crucial for intestinal homeostasis during hosts’ lifetime. It is responsible for producing metabolites that benefits and protects the host from harm microbial colonization. Knowledge about the interactions between human gut microbes and the developing nervous system is still scarce. Nevertheless, animal models have shown that gut bacteria and microbial metabolites are strongly associated with Central Nervous System (CNS) homeostasis. Endotoxins such as Lipopolysaccharides (LPS) are hypothesized to have a major role in neurodegeneration, however, conclusions must be taken with care due to differences in sensitivity between humans and mice. In this review we focus on the role of gut microbiota on the neurodevelopment of mice when ethanol consumption is one of the major stressors during prenatal period. We detail the range of the endotoxin hypothesis in describing endotoxins’ contribution to neurodegeneration and the influence that kynurenine pathway has on the process.
Keywords
prenatal alcohol consumption; gut microbiome; neurodevelopment; FASD; mice
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
