Version 1
: Received: 7 December 2022 / Approved: 8 December 2022 / Online: 8 December 2022 (09:46:26 CET)
Version 2
: Received: 12 June 2023 / Approved: 13 June 2023 / Online: 13 June 2023 (10:49:12 CEST)
Abohalaka, R. Bronchial epithelial and airway smooth muscle cell interactions in health and disease, HELIYON (2023), doi: https://doi.org/10.1016/j.heliyon.2023.e19976.
Abohalaka, R. Bronchial epithelial and airway smooth muscle cell interactions in health and disease, HELIYON (2023), doi: https://doi.org/10.1016/j.heliyon.2023.e19976.
Abohalaka, R. Bronchial epithelial and airway smooth muscle cell interactions in health and disease, HELIYON (2023), doi: https://doi.org/10.1016/j.heliyon.2023.e19976.
Abohalaka, R. Bronchial epithelial and airway smooth muscle cell interactions in health and disease, HELIYON (2023), doi: https://doi.org/10.1016/j.heliyon.2023.e19976.
Abstract
Chronic pulmonary diseases such as asthma, COPD, and Idiopathic pulmonary fibrosis are significant causes of mortality and morbidity worldwide. Currently, there is no radical treatment for many chronic pulmonary diseases, and the treatment options focus on relieving the symptoms and improving lung function. Therefore, efficient therapeutic agents are highly needed. Bronchial epithelial cells and airway smooth muscle cells and their crosstalk play a significant role in the pathogenesis of these diseases. Thus, targeting the interactions of these two cell types could open the door to a new generation of effective therapeutic options. However, the studies on how these two cell types interact and how their crosstalk adds up to respiratory diseases are not well established. With the rise of modern research tools and technology, such as lab-on-chip, organoids, co-culture techniques, and advanced immunofluorescence imaging, a substantial degree of evidence about these cell interactions emerged. Hence, this contribution aims to review the growing evidence of bronchial epithelial cells and airway smooth muscle cells crosstalk under normal and pathophysiological conditions. The review first deliberates the effects of both healthy and stressed epithelial cells on airway smooth muscle cells, taking into account three themes; contraction, migration, and proliferation. Then, it discusses the impact of airway smooth muscle cells on the epithelium in inflammatory settings. Later, it examines the role of airway smooth muscle cells in the early development of bronchial epithelial cells and their recovery after injury.
Biology and Life Sciences, Cell and Developmental Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
