Version 1
: Received: 4 December 2022 / Approved: 6 December 2022 / Online: 6 December 2022 (01:33:04 CET)
How to cite:
Antsiferova, A. A.; Kopaeva, M. Y.; Kashkarov, P. K. Relationships between Effects of Ag Nanoparticles and Ag Salt on Behavioral and Cognitive Functions of Mice and Ageing. Preprints2022, 2022120084. https://doi.org/10.20944/preprints202212.0084.v1
Antsiferova, A. A.; Kopaeva, M. Y.; Kashkarov, P. K. Relationships between Effects of Ag Nanoparticles and Ag Salt on Behavioral and Cognitive Functions of Mice and Ageing. Preprints 2022, 2022120084. https://doi.org/10.20944/preprints202212.0084.v1
Antsiferova, A. A.; Kopaeva, M. Y.; Kashkarov, P. K. Relationships between Effects of Ag Nanoparticles and Ag Salt on Behavioral and Cognitive Functions of Mice and Ageing. Preprints2022, 2022120084. https://doi.org/10.20944/preprints202212.0084.v1
APA Style
Antsiferova, A. A., Kopaeva, M. Y., & Kashkarov, P. K. (2022). Relationships between Effects of Ag Nanoparticles and Ag Salt on Behavioral and Cognitive Functions of Mice and Ageing. Preprints. https://doi.org/10.20944/preprints202212.0084.v1
Chicago/Turabian Style
Antsiferova, A. A., Marina Yu. Kopaeva and Pavel K. Kashkarov. 2022 "Relationships between Effects of Ag Nanoparticles and Ag Salt on Behavioral and Cognitive Functions of Mice and Ageing" Preprints. https://doi.org/10.20944/preprints202212.0084.v1
Abstract
Silver in different forms is used for medical purposes from ancient times. It is not yet well known, which form of silver is more biocompatible and less toxic. Here we considered silver nanoparticles and silver citrate. Also, the relationships of neurotoxicity of silver compaunds with ageing factor is not yet described. To assess the role of nanoform in neurotoxicity of silver and role of ageing a long-term experiment was conducted. We had four control groups of intact mice and four experimental groups which were exposed to silver nanoparticles and silver citrate for two months. Four groups of mice were introduced into the experiment since the age of five months to assess ageing factors. It was shown that the nanoform does play a certain role in neurotoxicity of silver. Silver citrate seems to be a more preferable silver compound. Ageing can be regarded as a positive factor that neutralizes toxic action of silver compounds. It may be due to the development of physiological/cognitive functions with the age as well as adaptation to unnatural content in the individual cages that is definitely stressful for mice.
Medicine and Pharmacology, Pharmacology and Toxicology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
