Is there a Role of Warburg Effect in Prostate Cancer Aggressiveness? Analysis of Expression of Enzymes of Lipidic Metabolism by Immunohistochemistry in Prostate Cancer Patients (DIAMOND Study)

Giorgio Ivan Russo; Maria Giovanna Asmundo; Arturo Lo Giudice; Giuseppe Trefiletti; Sebastiano Cimino; Matteo Ferro; Riccardo Lombardo; Cosimo De Nunzio; Giuseppe Morgia; Eliana Piombino; Maria Failla; Rosario Caltabiano; Giuseppe Broggi

doi:10.20944/preprints202212.0068.v1

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preprints.org > biology and life sciences > immunology and microbiology > doi: 10.20944/preprints202212.0068.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Is there a Role of Warburg Effect in Prostate Cancer Aggressiveness? Analysis of Expression of Enzymes of Lipidic Metabolism by Immunohistochemistry in Prostate Cancer Patients (DIAMOND Study)

Giorgio Ivan Russo

^* ,

Maria Giovanna Asmundo

Version 1 : Received: 27 November 2022 / Approved: 5 December 2022 / Online: 5 December 2022 (08:50:39 CET)

A peer-reviewed article of this Preprint also exists.

Russo, G.I.; Asmundo, M.G.; Lo Giudice, A.; Trefiletti, G.; Cimino, S.; Ferro, M.; Lombardo, R.; De Nunzio, C.; Morgia, G.; Piombino, E.; Failla, M.; Caltabiano, R.; Broggi, G. Is There a Role of Warburg Effect in Prostate Cancer Aggressiveness? Analysis of Expression of Enzymes of Lipidic Metabolism by Immunohistochemistry in Prostate Cancer Patients (DIAMOND Study). Cancers 2023, 15, 948. Russo, G.I.; Asmundo, M.G.; Lo Giudice, A.; Trefiletti, G.; Cimino, S.; Ferro, M.; Lombardo, R.; De Nunzio, C.; Morgia, G.; Piombino, E.; Failla, M.; Caltabiano, R.; Broggi, G. Is There a Role of Warburg Effect in Prostate Cancer Aggressiveness? Analysis of Expression of Enzymes of Lipidic Metabolism by Immunohistochemistry in Prostate Cancer Patients (DIAMOND Study). Cancers 2023, 15, 948.

Abstract

Prostate Cancer (PCa) is still ranked as the first cancer in male population and evidences have suggested an alteration of glycemic and lipidic metabolism that are related to its progression and prognosis. Aim of the study is to investigate associations between enzymes’ expression, especially involved in the lipidic pathway, and PCa aggressiveness. We retrospectively analyzed data from 390 patients with PCa or benign prostatic hyperplasia (BPH) at the Department of Urology, University of Catania. Immunohistochemical slides were evaluated for the expression of proteins related to glucose and lipidic metabolism. A total of 286 were affected by PCa while 104 by BPH. We demonstrated that ATP-lyase (odds ratio [OR]: 1.71; p<0.01), fatty acide sinthase (OR: 4.82; p<0.01), carnitine palmitoyl transferase-1a (OR: 2.27; p<0.05) were associated with androgen receptor (AR) expression. We found that steaoryl Co-A desaturase expression in PCa patients with total cholesterol ≥ 200 mg/dl was independently associated with ISUP ≥4 (OR: 4.22; p=0.049). We found that CPT-1a+ was associated with biochemical recurrence (hazard ratio: 1.94; p=0.03]). Our results support the evidences that the manipulation of lipidic metabolism could serve in the future to contrast PCa progression.

Keywords

prostate cancer; Warburg effect; prognosis; radical prostatectomy; lipidic; metabolism; mortality

Subject

Biology and Life Sciences, Immunology and Microbiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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