Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

A Procedure for Estimating Fundamental Variability

Version 1 : Received: 23 November 2022 / Approved: 24 November 2022 / Online: 24 November 2022 (14:33:00 CET)

How to cite: Uhlig, S.; Colson, B.; Gowik, P. A Procedure for Estimating Fundamental Variability. Preprints 2022, 2022110460 (doi: 10.20944/preprints202211.0460.v1). Uhlig, S.; Colson, B.; Gowik, P. A Procedure for Estimating Fundamental Variability. Preprints 2022, 2022110460 (doi: 10.20944/preprints202211.0460.v1).

Abstract

The question whether a given set of test items can be considered “identical” is often addressed in terms of the homogeneity of the test material from which said items were taken. However, for some types of matrices – in particular, for matrices consisting of minute separate particles, only some of which carry the analyte under consideration – even in the case of homogenous test material, an irreducible source of variability between test items may remain: the fundamental variability. In this paper, the concept of fundamental variability is explained, and procedures for reducing and characterizing it are described.

Keywords

Fundamental variability; homogeneity; variance; method validation; proficiency testing; measurement uncertainty

Subject

CHEMISTRY, Analytical Chemistry

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