Version 1
: Received: 17 November 2022 / Approved: 18 November 2022 / Online: 18 November 2022 (10:05:11 CET)
How to cite:
Tzenios, N.; Tazanios, M.; Chahine, M. The Relationship between Association between Blood Pressure and Risk of Cancer Development. Preprints2022, 2022110353. https://doi.org/10.20944/preprints202211.0353.v1
Tzenios, N.; Tazanios, M.; Chahine, M. The Relationship between Association between Blood Pressure and Risk of Cancer Development. Preprints 2022, 2022110353. https://doi.org/10.20944/preprints202211.0353.v1
Tzenios, N.; Tazanios, M.; Chahine, M. The Relationship between Association between Blood Pressure and Risk of Cancer Development. Preprints2022, 2022110353. https://doi.org/10.20944/preprints202211.0353.v1
APA Style
Tzenios, N., Tazanios, M., & Chahine, M. (2022). The Relationship between Association between Blood Pressure and Risk of Cancer Development. Preprints. https://doi.org/10.20944/preprints202211.0353.v1
Chicago/Turabian Style
Tzenios, N., Mary Tazanios and Mohamad Chahine. 2022 "The Relationship between Association between Blood Pressure and Risk of Cancer Development" Preprints. https://doi.org/10.20944/preprints202211.0353.v1
Abstract
Background of the Study: We investigated the link between hypertension and cancer since it has been suggested that hypertension may raise the long-term risk of cancer. Previous large observational cohort studies found that greater blood pressure (BP) was related to a higher risk of cancer. Mendelian randomization (MR) was utilized to produce less confounded blood pressure estimates (BP) on overall and site-specific malignancies. The study aims to draw conclusions on the relationship between high blood pressure and cancer. Methods: Studies on high blood pressure and various malignancies are inconclusive, except for renal cell carcinoma. However, given that most meta-analyses only contained a limited number of trials, some relative risks had small to moderate magnitudes, and several may have been impacted by residual confounding, careful interpretation is necessary. The study was conducted using the meta-analysis technique. Cochran's Q test and I2 test were used to assess statistical heterogeneity between studies in the current investigation for research involving two or more cause and outcome combinations. Results: Positive correlations were also reported between high blood pressure and esophageal adenocarcinoma, squamous cell carcinoma, liver, and squamous cell carcinoma. However, most studies lacked multivariable adjustments. Physical and numerical risk of cardiovascular disease is linked to bowel cancer but no other cancers. According to a meta-analysis, hypertensive persons could also be at increased danger of gastrointestinal and breast cancer. Most meta-analyses comprised several trials with moderate or mild hazard ratios.ConclusionDifferent types of cancers have been noted to be directly caused by hypertension. In addition, some treatments have also been associated with the side effects of cancer treatments to cause hypertension. Women facing hypertension have an increased risk of getting breast cancer. Although some cancers showed a real relationship with hypertension, others had no connection at all.
Keywords
high blood pressure; Cancer; malignancies; hypertension
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
