Preprint Brief Report Version 1 Preserved in Portico This version is not peer-reviewed

Alterations in Kidney Structures Caused by Age Vary According to Sex and Dehydration Condition

Susana Quirós Cognuck
* ORCID logo ,
Lucas Ferreira de Almeida
ORCID logo ,
Wagner L. Reis
,
Márcia S. Silva
,
Gislaine Almeida Pereira
ORCID logo ,
Sandra V. Zorro
,
André S. Mecawi
,
Terezila Machado Coimbra
,
Lucila L.K. Elias
,
José Antunes Antunes Rodrigues
ORCID logo
Version 1 : Received: 10 November 2022 / Approved: 11 November 2022 / Online: 11 November 2022 (03:53:06 CET)

A peer-reviewed article of this Preprint also exists.

Cognuck, S.Q.; Almeida, L.F.; Reis, W.L.; Silva, M.S.; Almeida-Pereira, G.; Zorro, S.V.; Mecawi, A.S.; Coimbra, T.M.; Elias, L.L.K.; Antunes-Rodrigues, J. Alterations in Kidney Structures Caused by Age Vary According to Sex and Dehydration Condition. Int. J. Mol. Sci. 2022, 23, 15672. Cognuck, S.Q.; Almeida, L.F.; Reis, W.L.; Silva, M.S.; Almeida-Pereira, G.; Zorro, S.V.; Mecawi, A.S.; Coimbra, T.M.; Elias, L.L.K.; Antunes-Rodrigues, J. Alterations in Kidney Structures Caused by Age Vary According to Sex and Dehydration Condition. Int. J. Mol. Sci. 2022, 23, 15672.

Abstract

Aging is a complex biological process, with gradual and progressive decline in structure and function in many organ systems. Our objective is to determine if structural changes produced by aging, vary with sex, in a stressful situation such as dehydration. The expression of Slc12a3 mRNA in renal cortex, α-smooth muscle actin (α-SMA) and fibronectin, was evaluated in male and female rats aged 3 and 18 months submitted or not to water deprivation (WD) for 48 hours. When comparing ages, 18-month-old males showed lower expression of Slc12a3 mRNA than 3-month-old males, and control and WD 18-moth-old male and female rats exhibited higher expression of α-SMA than respective 3-month-old rats. Fibronectin was higher in both control and WD 18-month-old males than respective 3-month-old males. In females, only control 18-month-old rats showed higher fibronectin than control 3-month-old rats. When we compared sex, control and WD 3-month-old female rats had lower expression of Slc12a3 mRNA than re-spective males. WD 18-month-old male rats presented higher expression of fibronectin and α-SMA than WD 18-month-old female rats. When we compared hydric condition, WD 18-month-old males displayed lower relative expression of Slc12a3 mRNA and higher α-SMA expression than control 18-month-old males. Aging, sex, and dehydration lead to alteration in kidney structure.

Keywords

aging; body composition; kidney; sex differences

Subject

Biology and Life Sciences, Anatomy and Physiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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