Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Chorioamnionitis and Fetal Lung: from Animal Models to Human Fetuses

Version 1 : Received: 5 November 2022 / Approved: 8 November 2022 / Online: 8 November 2022 (02:33:57 CET)

How to cite: Kymioni, V.; Sarafidis, K.; Papamitsou, T.; Sioga, A. Chorioamnionitis and Fetal Lung: from Animal Models to Human Fetuses. Preprints 2022, 2022110139. https://doi.org/10.20944/preprints202211.0139.v1 Kymioni, V.; Sarafidis, K.; Papamitsou, T.; Sioga, A. Chorioamnionitis and Fetal Lung: from Animal Models to Human Fetuses. Preprints 2022, 2022110139. https://doi.org/10.20944/preprints202211.0139.v1

Abstract

There is disagreement on the associations between chorioamnionitis and pneumonia/sepsis, respiratory distress syndrome (RDS), and bronchopulmonary (BPD)dysplasia, three pulmonary outcomes of concern for preterm newborns. Determining clear correlations is challenging due to the intricacy of the prenatal, postnatal, and therapeutic practices that affect the diagnosis of RDS, pneumonia/sepsis, and BPD, two long-term outcomes, as well as their short- and long-term consequences. Owing to the interconnected nature of the variables, the vaguely defined fetal exposures, and the imprecise identification of disorders like RDS and BPD, multivariant studies of huge data sets are unreliable methods for defining associations. On the other hand, research using animal models offers reliable data regarding the effects of exploratory chorioamnionitis on the fetal lung. Understanding the clinical intricacy and the experimental consequences of chorioamnionitis together will help us understand on the impact on the fetal lung .

Keywords

chorioamnionitis; fetal lung; vascularization; alveolarization; lung inflammation

Subject

Medicine and Pharmacology, Pediatrics, Perinatology and Child Health

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