Elucidating the Role of Santalol as A Potent Inhibitor of Tyrosinase: In Vitro and In Silico Approaches

Nabeel Ali; Zainy Zehra; Anas Shamsi; Md Amjad Beg; Zahoor Ahmad Parray; Israil .; Md. Ali Imam; Naseem A. Gaur; Md Imtaiyaz Hassan; Anis Ahmad Chaudhary; Hassan A. Rudayni; Mohammed Ibrahim Alghonaim; Sulaiman A. Alsalamah; Asimul Islam

doi:10.20944/preprints202211.0137.v1

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preprints.org > medicine and pharmacology > dermatology > doi: 10.20944/preprints202211.0137.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Elucidating the Role of Santalol as A Potent Inhibitor of Tyrosinase: In Vitro and In Silico Approaches

Mohammed Ibrahim Alghonaim

Sulaiman A. Alsalamah

Asimul Islam

Version 1 : Received: 3 November 2022 / Approved: 8 November 2022 / Online: 8 November 2022 (02:23:25 CET)

A peer-reviewed article of this Preprint also exists.

Ali, N.; Zehra, Z.; Shamsi, A.; Beg, M.A.; Parray, Z.A.; Israil; Imam, M.A.; Gaur, N.A.; Hassan, M.I.; Chaudhary, A.A.; Rudayni, H.A.; Alghonaim, M.I.; Alsalamah, S.A.; Islam, A. Elucidating the Role of Santalol as a Potent Inhibitor of Tyrosinase: In Vitro and In Silico Approaches. Molecules 2022, 27, 8915. Ali, N.; Zehra, Z.; Shamsi, A.; Beg, M.A.; Parray, Z.A.; Israil; Imam, M.A.; Gaur, N.A.; Hassan, M.I.; Chaudhary, A.A.; Rudayni, H.A.; Alghonaim, M.I.; Alsalamah, S.A.; Islam, A. Elucidating the Role of Santalol as a Potent Inhibitor of Tyrosinase: In Vitro and In Silico Approaches. Molecules 2022, 27, 8915.

Abstract

This research work focuses on the potential application of an organic compound, santalol obtained from santalum album in the inhibition of the enzyme tyrosinase which is actively involved in the biosynthesis of the melanin pigment. Over-production of melanin causes undesirable pigmentation in humans as well as other organisms that significantly downgrade their aesthetic value. The study is designed to explain the purification of tyrosinase from the mushroom Agaricus bisporus, followed by activity assay and enzyme kinetic to give insight into the santalol modulated tyrosinase inhibition in a dose dependent manner. The multi-spectroscopic techniques like UV-vis, fluorescence, and isothermal calorimetry are employed to deduce the efficiency of santalol as potential candidate against the tyrosinase enzyme activity. Experimental results are further verified by molecular docking. Santalol derived from the essential oils of santalum album, is widely used as remedy for skin disorders and potion for fair complexion since ancient times. Based on enzyme kinetics and biophysical characterization, this is the first scientific evidence where santalol inhibits tyrosinase, which may be employed in agriculture, food, and cosmetic industries by prevent excess melanin formation or browning.

Keywords

Mushroom tyrosinase; Melanogenesis; Tyrosinase inhibitor; Multi-spectroscopic techniques; Natural compounds; tyrosinase inhibitor

Subject

Medicine and Pharmacology, Dermatology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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