Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Biodegradable Polymer Nanosheets Incorporated with Zn-Containing Nanoparticles for Biomedical Applications

M.Q. Hafzan Bin Ishak
,
Prabakaran Shankar
ORCID logo ,
Marat E. Turabayev
,
Takahiro Kondo
,
Mitsuhiro Honda
,
Stanislav Gurbatov
,
Yosuke Okamura
,
Satoru Iwamori
,
Sergei A. Kulinich
* ORCID logo
Version 1 : Received: 4 November 2022 / Approved: 7 November 2022 / Online: 7 November 2022 (11:20:14 CET)

A peer-reviewed article of this Preprint also exists.

Ishak, M.Q.H.; Shankar, P.; Turabayev, M.E.; Kondo, T.; Honda, M.; Gurbatov, S.O.; Okamura, Y.; Iwamori, S.; Kulinich, S.A. Biodegradable Polymer Nanosheets Incorporated with Zn-Containing Nanoparticles for Biomedical Applications. Materials 2022, 15, 8101. Ishak, M.Q.H.; Shankar, P.; Turabayev, M.E.; Kondo, T.; Honda, M.; Gurbatov, S.O.; Okamura, Y.; Iwamori, S.; Kulinich, S.A. Biodegradable Polymer Nanosheets Incorporated with Zn-Containing Nanoparticles for Biomedical Applications. Materials 2022, 15, 8101.

Abstract

So far, poly(L-lactic acid), PLLA, nanosheets proved to be promising for wound healing. Such biodegradable materials are easy-to-prepare, bio-friendly, cost-effective, simple to apply and were shown to protect burn wounds and facilitate their healing. At the same time, certain metal ions are known to be essential for wound healing, which is why this study was motivated by the idea of incorporating PLLA nanosheets with Zn2+ ion containing nanoparticles. Upon being applied on wound, such polymer nanosheets should release Zn2+ ions, which is expected to improve wound healing. The work thus focused on preparing PLLA nanosheets embedded with several kinds of Zn-containing nanoparticles, their characterization and ion-release behavior. ZnCl2 and ZnO nanoparticles were chosen as model particles with different solubility in water, both types showing similar ion release dynamics in liquid medium with pH around 7.4.

Keywords

biodegradable polymer nanosheets; wound healing; laser ablation in liquid; nanoparticles; ZnO; ZnCl2

Subject

Chemistry and Materials Science, Surfaces, Coatings and Films

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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