Preprint Article Version 2 Preserved in Portico This version is not peer-reviewed

A New Understanding of Serum Creatinine Levels as a Predictive Factor of Mortality Outcomes in Aortic Disease

Cosmin Banceu
* ORCID logo ,
Marius Harpa
* ,
Radu Deac
,
Klara Brinzaniuc
,
Ioan Tilea
,
Andreea Varga
ORCID logo ,
Dan Alexandru Szabo
ORCID logo ,
Diana Banceu
,
Daiana Cristutiu
,
Alexandra Stoica
,
Marvin Oprean
ORCID logo ,
Horatiu Suciu
Version 1 : Received: 30 October 2022 / Approved: 1 November 2022 / Online: 1 November 2022 (01:10:43 CET)
Version 2 : Received: 10 November 2022 / Approved: 14 November 2022 / Online: 14 November 2022 (01:12:17 CET)

How to cite: Banceu, C.; Harpa, M.; Deac, R.; Brinzaniuc, K.; Tilea, I.; Varga, A.; Szabo, D.A.; Banceu, D.; Cristutiu, D.; Stoica, A.; Oprean, M.; Suciu, H. A New Understanding of Serum Creatinine Levels as a Predictive Factor of Mortality Outcomes in Aortic Disease. Preprints 2022, 2022110003. https://doi.org/10.20944/preprints202211.0003.v2 Banceu, C.; Harpa, M.; Deac, R.; Brinzaniuc, K.; Tilea, I.; Varga, A.; Szabo, D.A.; Banceu, D.; Cristutiu, D.; Stoica, A.; Oprean, M.; Suciu, H. A New Understanding of Serum Creatinine Levels as a Predictive Factor of Mortality Outcomes in Aortic Disease. Preprints 2022, 2022110003. https://doi.org/10.20944/preprints202211.0003.v2

Abstract

Acute kidney injury (AKI) is a complication that can occur after cardiac surgery and requires ongoing research in light of the exponential expansion of technological advancements and knowledge in medicine. In this study, we aim to evaluate the outcomes of treated electives of emergency aortic disease with high serum creatinine levels (SCr). Methods: The cohort includes 183 patients, all of whom have an aortic disease and whose SCr levels were checked upon admission on the first day in the intensive care unit (ICU) and upon discharge from the hospital. We examined the correlation of SCr levels with in-hospital mortality and immediate mortality at least six months after discharge as well as with cross-clamp time and bypass time.Results: A high SCr level upon admission is a significant predictive factor of n-hospital mortality (p = 0.001) but not immediate mortality (p = 0.409). A statistically significant correlation was also observed between elevated SCr level on the first day of ICU and aortic disease (p = 0.041) but not immediate mortality (p = 0.119). We observed a significant correlation between aortic disease and in-hospital mortality (p < 0.001), but no correlation was found between high SCr level on the first day of ICU and immediate mortality (p = 0.119). The cross-clamp time is statistically significant correlated with elevated SCr level (p = 0.013) and in-hospital mortality (p = 0.001) but not immediate mortality (p = 0.847). Furthermore, the bypass time is negatively correlated with a high SCr level on the first day of ICU (p = 0.090), in-hospital mortality (p = 0.410), and immediate mortality (p = 0.625). We also found that aortic disease is not correlated with elevated creatinine levels at ICU discharge (p = 0.152) or long-term mortality (p = 0.106). Conclusions: Although this study only included a small portion of the elaborate aspects of surgical and medical management developed around cardiac patients who received invasive treatment, the conclusions reached are nevertheless clearly relevant, as evidenced by the significantly correlations uncovered. In order to manage AKI after AAS and improve the outcome, the SCr level could be used as a marker for renoprotective strategy. Moving forward, these results serve as a first step in motivating us to expand the range of our research, collect newly relevant data, and use it to benefit patients.

Keywords

aortic diseases; serum creatinine; acute kidney injury; cardiac surgery; in-hospital mortality; cross-clamp time

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comments (1)

Comment 1
Received: 14 November 2022
Commenter: Banceu Cosmin
Commenter's Conflict of Interests: Author
Comment: The article went through the English editing process and had no context changes
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