Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Migraine and Inflammation: The Clinical Utility of Serial Systemic Immune Inflammatory Indices (SSIIi) during an Inpatient Setting

Version 1 : Received: 29 October 2022 / Approved: 31 October 2022 / Online: 31 October 2022 (11:17:24 CET)

How to cite: Wijeratne, T.; Wijeratne, C.; Karimi, L.; Apostolopolous, V.; Sales, C. Migraine and Inflammation: The Clinical Utility of Serial Systemic Immune Inflammatory Indices (SSIIi) during an Inpatient Setting. Preprints 2022, 2022100486. https://doi.org/10.20944/preprints202210.0486.v1 Wijeratne, T.; Wijeratne, C.; Karimi, L.; Apostolopolous, V.; Sales, C. Migraine and Inflammation: The Clinical Utility of Serial Systemic Immune Inflammatory Indices (SSIIi) during an Inpatient Setting. Preprints 2022, 2022100486. https://doi.org/10.20944/preprints202210.0486.v1

Abstract

Background: Migraine is the commonest complex neurological disorder affecting over a billion people worldwide. Neuroinflammation has long been considered to play an important role in the pathophysiology of migraine. The main aim of this single-centre, proof of concept, retrospective study was to determine the possible clinical utility of systemic immune-inflammatory response in migraine with and without aura in a hospitalized cohort. We measured the role of universally available serial white blood cell counts to calculate the serial systemic immune-inflammatory indices (SSIIi) and the potential association between aura and SSIIi changes in a cohort of migraine patients admitted to tertiary care center in Melbourne Australia.Main body: We retrospectively assessed patients' medical records presenting to Western Health with migraine over an 18 month period. Patients were classified as either having migraine with aura (MA) or without aura (MO) based on ICHD-3 criteria. Baseline demographics and brain imaging findings in each group were evaluated. Patients with two sets of white blood cell counts during the admission were included in the analysis. SSIIi were calculated as, neutrophil counts x platelet counts / lymphocyte counts. Correlation between SSIIi and MA and MO were assessed using SPSS27.Conclusion: SSIIi were elevated in MA and MO followed by a downward trend in both groups, with MA being statistically significant. This proof-of-concept study suggests the potential role of systemic inflammation in pathobiology of migraine. SSIIi appear to show clinical utility. Further comprehensive ,controlled , multicenter studies are required to clarify the exact role of systemic inflammatory response and the clinical utility of SSIIi in a subset of migraine in the Emergency department setting.

Keywords

Migraine; systemic inflmmation; serial systemic immune inflammatory indices; aura

Subject

Biology and Life Sciences, Immunology and Microbiology

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.