Version 1
: Received: 29 October 2022 / Approved: 31 October 2022 / Online: 31 October 2022 (06:16:35 CET)
How to cite:
Ibrahim, I.; Syamala, S.; Ayariga, J.; Xu, J.; Boakai, R.; Meenakshisundaram, S.; Ajayi, O. Modulatory Effect of Gut Microbiota on the Gut-Brain, Gut-Bone Axes, and the Impact of Cannabinoids. Preprints2022, 2022100465. https://doi.org/10.20944/preprints202210.0465.v1
Ibrahim, I.; Syamala, S.; Ayariga, J.; Xu, J.; Boakai, R.; Meenakshisundaram, S.; Ajayi, O. Modulatory Effect of Gut Microbiota on the Gut-Brain, Gut-Bone Axes, and the Impact of Cannabinoids. Preprints 2022, 2022100465. https://doi.org/10.20944/preprints202210.0465.v1
Ibrahim, I.; Syamala, S.; Ayariga, J.; Xu, J.; Boakai, R.; Meenakshisundaram, S.; Ajayi, O. Modulatory Effect of Gut Microbiota on the Gut-Brain, Gut-Bone Axes, and the Impact of Cannabinoids. Preprints2022, 2022100465. https://doi.org/10.20944/preprints202210.0465.v1
APA Style
Ibrahim, I., Syamala, S., Ayariga, J., Xu, J., Boakai, R., Meenakshisundaram, S., & Ajayi, O. (2022). Modulatory Effect of Gut Microbiota on the Gut-Brain, Gut-Bone Axes, and the Impact of Cannabinoids. Preprints. https://doi.org/10.20944/preprints202210.0465.v1
Chicago/Turabian Style
Ibrahim, I., Sreepriya Meenakshisundaram and Olufemi Ajayi. 2022 "Modulatory Effect of Gut Microbiota on the Gut-Brain, Gut-Bone Axes, and the Impact of Cannabinoids" Preprints. https://doi.org/10.20944/preprints202210.0465.v1
Abstract
The gut microbiome is a collection of microorganisms and parasites that reside in the gastrointestinal tract. There are many factors that can affect the composition of this community, such as age, sex, medications, and environmental triggers. The relationship between the human host and the gut microbiota is very important for both the survival and development of the organism. The disruption of this relationship can lead to the development of various inflammatory diseases. CBD and THC are used to treat muscle spasticity associated with multiple sclerosis. It is now clear these compounds also benefit patients with neuroinflammation. A study that investigated the role of gut microbiota in treating the inflammation and paralysis in a mouse model demonstrated that treatment with CBD and THC produced significant decrease in the inflammation levels. They also exhibited a significant increase in the number of anti-inflammatory cytokines. The presence of certain cannabinoids can suppress neuroinflammation and prevent microbial dysbiosis. Several studies have revealed the role of the gut microbiota in the development and maintenance of skeletal integrity and bone mineral density. The gut is a major source of nutrients, including vitamins B and K. It can also influence the development and maintenance of bone matrix. The presence of the gut microbiota can influence the actions of certain T regulatory cells, which can lead to the development of bone formation and proliferation. In addition, its metabolites can prevent bone loss. The gut microbiota can help maintain the bone's equilibrium and prevent the development of metabolic diseases, such as osteoporosis. In this review, the dual functions gut microbiota plays in the regulation of gut-bone axis and gut-brain axis and the impact of CBD on these roles are discussed in detail.
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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