Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Synthesis, Properties and Spatial Structure of 4-[(3,5-dimethyl-1,2-oxazol-4-yl)sulfonyl]cytisine

Marat K. Ibrayev
* ORCID logo ,
Оralgazy A. Nurkenov
,
Zhanara B. Rakhimberlinova
,
Altynaray T. Takibayeva
ORCID logo ,
Dastan M. Turdybekov
,
Tulegen M. Seilkhanov
ORCID logo ,
Meruyert B. Issabayeva
* ,
Assel A. Kelmyalene
Version 1 : Received: 25 October 2022 / Approved: 25 October 2022 / Online: 25 October 2022 (07:33:55 CEST)

A peer-reviewed article of this Preprint also exists.

Ibrayev, M.K.; Nurkenov, O.A.; Rakhimberlinova, Z.B.; Takibayeva, A.T.; Turdybekov, D.M.; Seilkhanov, T.M.; Issabayeva, M.B.; Kelmyalene, A.A.; Kezdikbayeva, A.T.; Mendibayeva, A.Z. Synthesis, Properties and Spatial Structure of 4-[(3,5-Dimethyl-1,2-oxazol-4-yl)sulfonyl]cytisine. Plants 2023, 12, 137. Ibrayev, M.K.; Nurkenov, O.A.; Rakhimberlinova, Z.B.; Takibayeva, A.T.; Turdybekov, D.M.; Seilkhanov, T.M.; Issabayeva, M.B.; Kelmyalene, A.A.; Kezdikbayeva, A.T.; Mendibayeva, A.Z. Synthesis, Properties and Spatial Structure of 4-[(3,5-Dimethyl-1,2-oxazol-4-yl)sulfonyl]cytisine. Plants 2023, 12, 137.

Abstract

This article has been studied the synthesis of a new derivative of the known alkaloid cytisine contained in the seeds of plants of Cytisus laburnum L. and Thermopsis lanceolata R.Br., both of the Lugiminosae family. The new compound has been obtained from two biologically active compounds such as isoxazole and cytisine. It has been demonstrated that the reaction led to the single-stage method under very mild conditions to obtain some 4-[(3,5-dimethyl-1,2-oxazole-4-yl)sulfonyl]amides. This class of compounds is promising to obtain the new biologically active compounds. This article has examined in detail a structure with using the 1H and 13C NMR and two-dimensional NMR spectroscopy of COSY (1H-1H), HMQC (1H-13C) and NMVS (1H-13C). As a result, the homo- and heteronuclear spin-spin couplings should be established. The X-ray diffraction analysis has determined the spatial structure of a new derivative based on cytisine alkaloid. Thus, its hemorheological activity has been studied.

Keywords

sulfo-derivatives of azoles; alkaloid cytisine; spatial structure; hemorheological activity; 1H; 13C; 2D NMR spectroscopy; X-ray diffraction analysis

Subject

Chemistry and Materials Science, Organic Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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