Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Maternal Obesity and Gut Microbiota Are Associated With Fetal Brain Development

Sanjay Basak
ORCID logo ,
Ranjit Kumar Das
,
Antara Banerjee
,
Sujoy Paul
ORCID logo ,
Surajit Pathak
ORCID logo ,
Asim K. Duttaroy
* ORCID logo
Version 1 : Received: 13 October 2022 / Approved: 14 October 2022 / Online: 14 October 2022 (10:15:21 CEST)

A peer-reviewed article of this Preprint also exists.

Basak, S.; Das, R.K.; Banerjee, A.; Paul, S.; Pathak, S.; Duttaroy, A.K. Maternal Obesity and Gut Microbiota Are Associated with Fetal Brain Development. Nutrients 2022, 14, 4515. Basak, S.; Das, R.K.; Banerjee, A.; Paul, S.; Pathak, S.; Duttaroy, A.K. Maternal Obesity and Gut Microbiota Are Associated with Fetal Brain Development. Nutrients 2022, 14, 4515.

Abstract

Obesity in pregnancy induces metabolic syndrome, low-grade inflammation, altered endocrine factors, placental function, and the maternal gut microbiome. All these factors impact fetal growth and development, including brain development. The lipid metabolic transporters of the maternal-fetal-placental unit are dysregulated in obesity. Consequently, the transport of essential long-chain PUFAs for fetal brain development is disturbed. The mother’s gut microbiota is vital in maintaining postnatal energy homeostasis and maternal-fetal immune competence. Obesity during pregnancy changes the gut microbiota, affecting fetal brain development. Obesity and a high-fat diet in pregnancy can induce placental and intrauterine inflammation and thus influence the neurodevelopmental outcomes of the offspring. Several epidemiological studies observed an association between maternal obesity and adverse neurodevelopment. This review discusses the effects of maternal obesity and gut microbiota on fetal neurodevelopment outcomes. In addition, the possible mechanisms of the impacts of obesity and gut microbiota on fetal brain development are discussed.

Keywords

Obesity; gut microbiota; placenta; brain development; fatal development

Subject

Biology and Life Sciences, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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