Version 1
: Received: 7 October 2022 / Approved: 11 October 2022 / Online: 11 October 2022 (10:43:36 CEST)
How to cite:
Sun, K.; Ning, J.; Wang, X.; Chen, X. The Immune Microenvironment in Epstein–Barr Virus-Positive Gastric Cancer: Current Status and Future Perspectives. Preprints2022, 2022100154. https://doi.org/10.20944/preprints202210.0154.v1
Sun, K.; Ning, J.; Wang, X.; Chen, X. The Immune Microenvironment in Epstein–Barr Virus-Positive Gastric Cancer: Current Status and Future Perspectives. Preprints 2022, 2022100154. https://doi.org/10.20944/preprints202210.0154.v1
Sun, K.; Ning, J.; Wang, X.; Chen, X. The Immune Microenvironment in Epstein–Barr Virus-Positive Gastric Cancer: Current Status and Future Perspectives. Preprints2022, 2022100154. https://doi.org/10.20944/preprints202210.0154.v1
APA Style
Sun, K., Ning, J., Wang, X., & Chen, X. (2022). The Immune Microenvironment in Epstein–Barr Virus-Positive Gastric Cancer: Current Status and Future Perspectives. Preprints. https://doi.org/10.20944/preprints202210.0154.v1
Chicago/Turabian Style
Sun, K., Xiuli Wang and Xiao-Bing Chen. 2022 "The Immune Microenvironment in Epstein–Barr Virus-Positive Gastric Cancer: Current Status and Future Perspectives" Preprints. https://doi.org/10.20944/preprints202210.0154.v1
Abstract
We have previously discussed the pathological characteristics, clinical characteristics, detection methods, pathogenesis, and treatment of Epstein–Barr virus (EBV)-positive gastric cancer, but we have not discussed the unique immune microenvironment in EBV-positive gastric cancer. Here, we reviewed studies on the immune microenvironment in EBV-positive gastric cancer and found that CD8+ T lymphocytes and a small number of CD204+ macrophages infiltrate the immune microenvironment in EBV-positive gastric cancer. Moreover, immune checkpoints, such as IDO1 and PD-L1, are expressed at high levels in EBV-positive gastric cancer. Lastly, we also analyzed the mechanisms underlying the formation of the immune microenvironment in EBV-positive gastric cancer. Our findings and conclusions have significance in clinical guidance and provide research direction for basic experiments.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
