Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Potential Inflammatory Biomarker in Patients with Attention Deficit Hyperactivity Disorder

Version 1 : Received: 28 September 2022 / Approved: 29 September 2022 / Online: 29 September 2022 (08:11:33 CEST)

A peer-reviewed article of this Preprint also exists.

Park, J.H. Potential Inflammatory Biomarker in Patients with Attention Deficit Hyperactivity Disorder. Int. J. Mol. Sci. 2022, 23, 13054. Park, J.H. Potential Inflammatory Biomarker in Patients with Attention Deficit Hyperactivity Disorder. Int. J. Mol. Sci. 2022, 23, 13054.

Abstract

Attention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder that can diminish the quality of life of both children and adults in academic, occupational, and social contexts. The kynurenine pathway (KP) contains a set of enzymatic reactions involved in tryptophan (TRP) degradation. It is known to be associated with the risk of developing ADHD. This review will address the KP and underlying mechanism of inflammation in ADHD. Potential inflammatory biomarkers reported in the most recent studies are summarized. Although a strong neuroimmunological basis has been established due to advances of recent neurobiological research, the pathophysiology of ADHD remains unclear.

Keywords

kynurenine pathway; inflammatory biomarkers; inflammation; ADHD; neurobiology; kynurenine

Subject

Medicine and Pharmacology, Pharmacology and Toxicology

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