Review
Version 1
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The Crosstalk Between Microbiome, Cancer Immunology, and Immunotherapeutics: Myth or Reality
Version 1
: Received: 5 September 2022 / Approved: 7 September 2022 / Online: 7 September 2022 (12:42:28 CEST)
A peer-reviewed article of this Preprint also exists.
Tojjari, A.; Abushukair, H.; Saeed, A. The Crosstalk between Microbiome and Immunotherapeutics: Myth or Reality. Cancers 2022, 14, 4641. Tojjari, A.; Abushukair, H.; Saeed, A. The Crosstalk between Microbiome and Immunotherapeutics: Myth or Reality. Cancers 2022, 14, 4641.
Abstract
Abstract: The gut microbiome refers to microorganisms and their genetic material influencing local and systemic inflammation. Inflammation is known to contribute to cancer development, progression, and treatment. Evidence suggests that modulating the gut microbiome may affect responses to various cancer therapies. The gut microbiota has been suggested to have an impact on immunotherapy efficacy, especially the currently widely used immune checkpoint inhibitors in various malignancies. Microbial Interventions like fecal microbiota transplantation, various probiotics, or even antibiotics can increase or de-crease the tumor's sensitivity to immunotherapy. However, not all tumors react in the same manner, highlighting the tumor microenvironment heterogeneity across tumor types and the influence this has on the crosstalk between the microbiome and therapy outcomes. In this study, we intend to review the association between the gut microbiota and immunotherapy response in cancer patients and the factors regulating this interaction.
Keywords
Cancer; Immunotherapy; Microbiome; Immune Checkpoint Inhibitor; Immunology; Therapy
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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