Aragão Pereira, J.P.; Franco Brandão, A.A.; Bevilacqua, J.S.; Côrrea-Giannella, M.L.C. A Multi-Agent Approach Used to Predict Long-Term Glucose Oscillation in Individuals with Type 1 Diabetes. Appl. Sci.2022, 12, 9641.
Aragão Pereira, J.P.; Franco Brandão, A.A.; Bevilacqua, J.S.; Côrrea-Giannella, M.L.C. A Multi-Agent Approach Used to Predict Long-Term Glucose Oscillation in Individuals with Type 1 Diabetes. Appl. Sci. 2022, 12, 9641.
Aragão Pereira, J.P.; Franco Brandão, A.A.; Bevilacqua, J.S.; Côrrea-Giannella, M.L.C. A Multi-Agent Approach Used to Predict Long-Term Glucose Oscillation in Individuals with Type 1 Diabetes. Appl. Sci.2022, 12, 9641.
Aragão Pereira, J.P.; Franco Brandão, A.A.; Bevilacqua, J.S.; Côrrea-Giannella, M.L.C. A Multi-Agent Approach Used to Predict Long-Term Glucose Oscillation in Individuals with Type 1 Diabetes. Appl. Sci. 2022, 12, 9641.
Abstract
The glucose-insulin regulatory system and its glucose oscillations is a recurring theme in the literature because of its impact on human lives, mostly the ones affected by diabetes mellitus. Several approaches were proposed, from mathematical to data-based models, with the aim of modeling the glucose oscillation curve. Having such a curve, it is possible to predict, when injecting insulin in type 1 diabetes (T1D) individuals. However, the literature presents prediction horizons no longer than 6 hours, which could be a problem considering their sleeping time. This work presents Tesseratus, a model that adopts a multi-agent approach to combine machine learning and mathematical modeling to predict the glucose oscillation up to 8 hours. Tesseratus uses the pharmacokinetics of insulins and data collected from T1D individuals. Its outcome can support endocrinologists while prescripting daily treatment for T1D individuals, and provide personalized recommendations for such individuals, to keep their glucose concentration in the ideal range. Tesseratus brings pioneering results for prediction horizons of 8 hours for nighttime, in an experiment with seven real T1D individuals. It is our claim that Tesseratus will be a reference for classification of glucose prediction model, supporting the mitigation of short- and long-term complications in the T1D individuals.
Keywords
Glucose Oscillation; Prediction; Multi-agent; Type 1 Diabetes; Personalized; Recommendation
Subject
Computer Science and Mathematics, Computer Science
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
,
*
,
,
