Bandaru, N.R.; Makam, P.; Akshinthala, P.; Katari, N.K.; Banoth, V.; Kolli, B.; Gundla, R. Molecular Hybrids of Pyazolo[3,4-b]pyridine and Triazole: Design, Synthesis and In Vitro Antibacterial Studies. Molecules2022, 27, 7647.
Bandaru, N.R.; Makam, P.; Akshinthala, P.; Katari, N.K.; Banoth, V.; Kolli, B.; Gundla, R. Molecular Hybrids of Pyazolo[3,4-b]pyridine and Triazole: Design, Synthesis and In Vitro Antibacterial Studies. Molecules 2022, 27, 7647.
Bandaru, N.R.; Makam, P.; Akshinthala, P.; Katari, N.K.; Banoth, V.; Kolli, B.; Gundla, R. Molecular Hybrids of Pyazolo[3,4-b]pyridine and Triazole: Design, Synthesis and In Vitro Antibacterial Studies. Molecules2022, 27, 7647.
Bandaru, N.R.; Makam, P.; Akshinthala, P.; Katari, N.K.; Banoth, V.; Kolli, B.; Gundla, R. Molecular Hybrids of Pyazolo[3,4-b]pyridine and Triazole: Design, Synthesis and In Vitro Antibacterial Studies. Molecules 2022, 27, 7647.
Abstract
Antimicrobial resistance is on the rise, and there aren't enough new treatments to combat it. This might send the modern world back to the pre-antibiotic age. The molecular hybrids of pyrazolo[3,4-b]pyridine and triazole have been designed, synthesized, and analyzed for their drug-like molecule nature and in vitro analyses for their inhibition potentials against S. Aureus and K. Pneumoniae. The compounds CY-R2-25 and CY-R2-28 have been identified as the high potential molecules in this series based on in vitro experiments. CY-R2-25 has zone of inhibition values of 15 0.82 and 14 0.7, whilst CY-R2-28 has the zone of inhibition values of 18 0.95 and 16 0.82 against S. Aureus and K. Pneumoniae, respectively. MIC and MIB values for CY-R2-25 and CY-R2-28 against S. Aureus and K. Pneumoniae are 0.25 and 0.5, respectively.
Keywords
pyrazolo[3,4-b]pyridine; triazole; in vitro; anti-bacterial; S. Aureus; K. Pneumoniae
Subject
Chemistry and Materials Science, Organic Chemistry
Copyright:
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