Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Molecular Hybrids of Pyrazolo[3,4-b]Pyridine and Triazole: Design, Synthesis and in vitro Antibacterial Studies

Narasimha Rao Bandaru
,
Parameshwar Makam
,
Parameswari Akshinthala
,
Naresh Kumar Katari
ORCID logo ,
Venkanna Banoth
,
Balakrishna Kolli
* ORCID logo ,
Rambabu Gundla
*
Version 1 : Received: 27 August 2022 / Approved: 29 August 2022 / Online: 29 August 2022 (10:51:23 CEST)

A peer-reviewed article of this Preprint also exists.

Bandaru, N.R.; Makam, P.; Akshinthala, P.; Katari, N.K.; Banoth, V.; Kolli, B.; Gundla, R. Molecular Hybrids of Pyazolo[3,4-b]pyridine and Triazole: Design, Synthesis and In Vitro Antibacterial Studies. Molecules 2022, 27, 7647. Bandaru, N.R.; Makam, P.; Akshinthala, P.; Katari, N.K.; Banoth, V.; Kolli, B.; Gundla, R. Molecular Hybrids of Pyazolo[3,4-b]pyridine and Triazole: Design, Synthesis and In Vitro Antibacterial Studies. Molecules 2022, 27, 7647.

Abstract

Antimicrobial resistance is on the rise, and there aren't enough new treatments to combat it. This might send the modern world back to the pre-antibiotic age. The molecular hybrids of pyrazolo[3,4-b]pyridine and triazole have been designed, synthesized, and analyzed for their drug-like molecule nature and in vitro analyses for their inhibition potentials against S. Aureus and K. Pneumoniae. The compounds CY-R2-25 and CY-R2-28 have been identified as the high potential molecules in this series based on in vitro experiments. CY-R2-25 has zone of inhibition values of 15 0.82 and 14 0.7, whilst CY-R2-28 has the zone of inhibition values of 18 0.95 and 16 0.82 against S. Aureus and K. Pneumoniae, respectively. MIC and MIB values for CY-R2-25 and CY-R2-28 against S. Aureus and K. Pneumoniae are 0.25 and 0.5, respectively.

Keywords

pyrazolo[3,4-b]pyridine; triazole; in vitro; anti-bacterial; S. Aureus; K. Pneumoniae

Subject

Chemistry and Materials Science, Organic Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF Download Supplementary

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Supplementary Files Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.