Version 1
: Received: 11 August 2022 / Approved: 15 August 2022 / Online: 15 August 2022 (12:00:33 CEST)
How to cite:
Foroughi Nezhad, A.; Dehghan, S. Trans-Differentiation of Non-Stem Cells to Nerve Cells or Neural Stem Cells through MicroRNA Reprogramming. Preprints2022, 2022080263. https://doi.org/10.20944/preprints202208.0263.v1
Foroughi Nezhad, A.; Dehghan, S. Trans-Differentiation of Non-Stem Cells to Nerve Cells or Neural Stem Cells through MicroRNA Reprogramming. Preprints 2022, 2022080263. https://doi.org/10.20944/preprints202208.0263.v1
Foroughi Nezhad, A.; Dehghan, S. Trans-Differentiation of Non-Stem Cells to Nerve Cells or Neural Stem Cells through MicroRNA Reprogramming. Preprints2022, 2022080263. https://doi.org/10.20944/preprints202208.0263.v1
APA Style
Foroughi Nezhad, A., & Dehghan, S. (2022). Trans-Differentiation of Non-Stem Cells to Nerve Cells or Neural Stem Cells through MicroRNA Reprogramming. Preprints. https://doi.org/10.20944/preprints202208.0263.v1
Chicago/Turabian Style
Foroughi Nezhad, A. and Sina Dehghan. 2022 "Trans-Differentiation of Non-Stem Cells to Nerve Cells or Neural Stem Cells through MicroRNA Reprogramming" Preprints. https://doi.org/10.20944/preprints202208.0263.v1
Abstract
Brain stem cells (neural stem cells or NSCs) and neurons of a chosen kind reprogramming is a potential technique for cell therapy. It is possible to reprogram non-neuronal cells, for example, by using a predetermined group of factors, nuclear transfer, and the induced transcriptional factors (TFs) expression in a related lineage of cells, and non-coding microRNAs (miRNAs). Researchers have additionally been attempting to improve reprogramming methods, whether it is by employing unique sets of biomolecules and particular TFs or by delivering relevant miRNA and Biomolecules. The technique of miRNA mediated is intriguing for its capability to quickly create a range of biologically desirable cell types for therapy from different lineages of cells. Current findings have made significant advancements towards changing the somatic cells to diverse particular neuronal subgroups with greater efficiency, using reprogramming of miRNA-mediated neural cells, despite the fact that the precise processes need to be discovered. To further understand how miRNAs might direct somatic cells to become neural, we need to look at the latest research on their function in neural reprogramming over the differentiated cells. Recent findings on the role of miRNAs in the initiation of cell reprogramming and the determination of the neuronal subtype's destiny are the primary focus of this comprehensive overview. Furthermore, we cover the far more latest results concerning certain miRNAs' activity in controlling different phases of neuronal differentiation, which contributes in comprehending the interaction network of miRNAs and their receptors.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
