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Progress and Impact of Latin American Natural Product Databases
Version 1
: Received: 11 August 2022 / Approved: 12 August 2022 / Online: 12 August 2022 (08:39:40 CEST)
A peer-reviewed article of this Preprint also exists.
Gómez-García, A.; Medina-Franco, J.L. Progress and Impact of Latin American Natural Product Databases. Biomolecules 2022, 12, 1202. Gómez-García, A.; Medina-Franco, J.L. Progress and Impact of Latin American Natural Product Databases. Biomolecules 2022, 12, 1202.
Abstract
Natural products (NPs) are a rich source of structurally novel molecules, and the chemical space they encompass is far from being fully explored. Over history, NPs have represented a significant source of bioactive molecules and have served as a source of inspiration for developing many drugs on the market. On the other hand, computer-aided drug design (CADD) has contributed to drug discovery research, mitigating costs and time. In this sense, compound databases represent a fundamental element for the CADD. This work reviews the progress toward developing compound databases of natural origin, particularly databases developed in Latin America, and their practical applications in the drug discovery area. We also survey the computational methods, emphasizing chemoinformatic approaches to profile natural product databases.
Keywords
chemoinformatics; compound databases; chemical space; diversity; drug discovery; openscience; pseudo-natural product
Subject
Chemistry and Materials Science, Theoretical Chemistry
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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