Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

SUMOylation in Skeletal Development, Homeostasis, and Disease

Version 1 : Received: 26 July 2022 / Approved: 28 July 2022 / Online: 28 July 2022 (09:04:33 CEST)

How to cite: Yang, T.; Liu, H.; Craig, S.E.L.; Molchanov, V.; Floramo, J.; Zhao, Y. SUMOylation in Skeletal Development, Homeostasis, and Disease. Preprints 2022, 2022070436 (doi: 10.20944/preprints202207.0436.v1). Yang, T.; Liu, H.; Craig, S.E.L.; Molchanov, V.; Floramo, J.; Zhao, Y. SUMOylation in Skeletal Development, Homeostasis, and Disease. Preprints 2022, 2022070436 (doi: 10.20944/preprints202207.0436.v1).

Abstract

The modification of proteins by small ubiquitin-related modifier (SUMO) molecules, SUMOylation, is a key post-translational modification involved in a variety of biological processes such as chromosomes organization, DNA replication and repair, transcription, nuclear transport, and cell signaling transduction. In recent years, emerging evidence has shown that SUMOylation regulates the development and homeostasis of the skeletal system, with its dysregulation causing skeletal diseases, suggesting that SUMOylation pathways may serve as a promising therapeutic target. In this review, we summarize the current understanding of the molecular mechanisms by which SUMOylation pathways regulate skeletal cells in the physiological and disease contexts.

Keywords

SUMO; MSC; osteoblast; chondrocyte; osteoclast; signaling pathway; arthritis; osteosarcoma; developmental disorders

Subject

BIOLOGY, Physiology

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