Liu, H.; Craig, S.E.L.; Molchanov, V.; Floramo, J.S.; Zhao, Y.; Yang, T. SUMOylation in Skeletal Development, Homeostasis, and Disease. Cells2022, 11, 2710.
Liu, H.; Craig, S.E.L.; Molchanov, V.; Floramo, J.S.; Zhao, Y.; Yang, T. SUMOylation in Skeletal Development, Homeostasis, and Disease. Cells 2022, 11, 2710.
Liu, H.; Craig, S.E.L.; Molchanov, V.; Floramo, J.S.; Zhao, Y.; Yang, T. SUMOylation in Skeletal Development, Homeostasis, and Disease. Cells2022, 11, 2710.
Liu, H.; Craig, S.E.L.; Molchanov, V.; Floramo, J.S.; Zhao, Y.; Yang, T. SUMOylation in Skeletal Development, Homeostasis, and Disease. Cells 2022, 11, 2710.
Abstract
The modification of proteins by small ubiquitin-related modifier (SUMO) molecules, SUMOylation, is a key post-translational modification involved in a variety of biological processes such as chromosomes organization, DNA replication and repair, transcription, nuclear transport, and cell signaling transduction. In recent years, emerging evidence has shown that SUMOylation regulates the development and homeostasis of the skeletal system, with its dysregulation causing skeletal diseases, suggesting that SUMOylation pathways may serve as a promising therapeutic target. In this review, we summarize the current understanding of the molecular mechanisms by which SUMOylation pathways regulate skeletal cells in the physiological and disease contexts.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
