Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Rapid Elevation of Vitamin D Level Reduces C-Reactive Protein Level in COVID-19 Patients With Vitamin D Insufficiency

Sintija Sauša
,
Svjatoslavs Kistkins
,
Olga Čirkova
,
Daina Kalniņa
,
Betija Jurge
,
Kristīne Ivanova
,
Zane Svirkle
,
Aija Frīdvalde
,
Vitalijs Borisovs
,
Rebeka Elīza Zariņa
,
Terēze Treimane
,
Sampsa Kaukua
,
Lelde Krūzmane
,
Ilva Trapiņa
,
Kristīne Geldnere
,
Valdis Pīrāgs
*
Version 1 : Received: 21 July 2022 / Approved: 22 July 2022 / Online: 22 July 2022 (13:21:04 CEST)

How to cite: Sauša, S.; Kistkins, S.; Čirkova, O.; Kalniņa, D.; Jurge, B.; Ivanova, K.; Svirkle, Z.; Frīdvalde, A.; Borisovs, V.; Zariņa, R.E.; Treimane, T.; Kaukua, S.; Krūzmane, L.; Trapiņa, I.; Geldnere, K.; Pīrāgs, V. Rapid Elevation of Vitamin D Level Reduces C-Reactive Protein Level in COVID-19 Patients With Vitamin D Insufficiency. Preprints 2022, 2022070342. https://doi.org/10.20944/preprints202207.0342.v1 Sauša, S.; Kistkins, S.; Čirkova, O.; Kalniņa, D.; Jurge, B.; Ivanova, K.; Svirkle, Z.; Frīdvalde, A.; Borisovs, V.; Zariņa, R.E.; Treimane, T.; Kaukua, S.; Krūzmane, L.; Trapiņa, I.; Geldnere, K.; Pīrāgs, V. Rapid Elevation of Vitamin D Level Reduces C-Reactive Protein Level in COVID-19 Patients With Vitamin D Insufficiency. Preprints 2022, 2022070342. https://doi.org/10.20944/preprints202207.0342.v1

Abstract

Background: According to newly published studies, patients with Coronavirus Disease 2019 (COVID-19) have significantly lower serum 25-hydroxyvitamin D 25(OH)D levels than those without the SARS-CoV-2 infection. Vitamin D insufficiency may be a predictor of poor prognosis in COVID-19 patients. Vitamin D supplementation is related to improved clinical outcomes in terms of intensive care unit (ICU) admission and death, particularly in individuals with moderate-to-severe forms of COVID-19 requiring hospitalization. Materials and methods: This placebo-controlled five-day study was performed on 100 hospitalized COVID-19 patients with vitamin D insufficiency randomized into two groups. Vitamin D in the form of a sublingual sprayable microemulsion (LYL love your life® sunD3 LYLmicro™) was given three times daily after breakfast, lunch, and dinner (daily dose 12,000 IU) to 52 patients with blood vitamin D levels below 30 ng/ml. 48 patients in the control group received a placebo spray in the same daily regiment. Results: We observed a statistically significant increase by 8.6 ng/ml in median vitamin D level after five days of high-dose vitamin D3 spray therapy. 90.2% of subjects reached normal serum levels of vitamin D. There was a strong correlation between changes in vitamin D and C-reactive protein (CRP) levels in individuals with moderately severe disease (p<0.05), while mild and severe cases showed no statistical significance comparing case and control groups. There were no statistically significant changes in ferritin and interleukin-6 (IL-6) levels. Conclusions: In this study, we demonstrated the possibility to rapidly increase circulating levels of vitamin D just in 5 days of high-dose intervention and found a statistically significant decrease of CRP levels in patients with moderately severe COVID-19. We were not able to detect statistically significant changes in ferritin and IL-6 levels during the 5-day vitamin D intervention.

Keywords

COVID-19; CRP; vitamin D insufficiency; vitamin D spray

Subject

Biology and Life Sciences, Food Science and Technology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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