Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

NIH SenNet Consortium: Mapping Senescent Cells in the Human Body to Understand Health and Disease

Version 1 : Received: 9 July 2022 / Approved: 11 July 2022 / Online: 11 July 2022 (12:12:47 CEST)

How to cite: Lee, P.; Blood, P.; Börner, K.; Campisi, J.; Chen, F.; Daldrup-Link, H.; De Jager, P.; Ding, L.; Duncan, F.E.; Eickelberg, O.; Fan, R.; Finkel, T.; Garovic, V.; Gehlenborg, N.; Glass, C.; Bar-Joseph, Z.; Katiyar, P.; Kim, S.; Königshoff, M.; Kuchel, G.; Lee, H.; Lee, J.H.; Ma, J.; Ma, Q.; Melov, S.; Metis, K.; Mora, A.L.; Musi, N.; Neretti, N.; Passos, J.F.; Rahman, I.; Rivera-Mulia, J.C.; Robson, P.; Rojas, M.; Roy, A.L.; Schilling, B.; Shi, P.; Silverstein, J.; Suryadevera, V.; Xie, J.; Wang, J.; Wong, A.I.; Niedernhofer, L. NIH SenNet Consortium: Mapping Senescent Cells in the Human Body to Understand Health and Disease. Preprints 2022, 2022070160 (doi: 10.20944/preprints202207.0160.v1). Lee, P.; Blood, P.; Börner, K.; Campisi, J.; Chen, F.; Daldrup-Link, H.; De Jager, P.; Ding, L.; Duncan, F.E.; Eickelberg, O.; Fan, R.; Finkel, T.; Garovic, V.; Gehlenborg, N.; Glass, C.; Bar-Joseph, Z.; Katiyar, P.; Kim, S.; Königshoff, M.; Kuchel, G.; Lee, H.; Lee, J.H.; Ma, J.; Ma, Q.; Melov, S.; Metis, K.; Mora, A.L.; Musi, N.; Neretti, N.; Passos, J.F.; Rahman, I.; Rivera-Mulia, J.C.; Robson, P.; Rojas, M.; Roy, A.L.; Schilling, B.; Shi, P.; Silverstein, J.; Suryadevera, V.; Xie, J.; Wang, J.; Wong, A.I.; Niedernhofer, L. NIH SenNet Consortium: Mapping Senescent Cells in the Human Body to Understand Health and Disease. Preprints 2022, 2022070160 (doi: 10.20944/preprints202207.0160.v1).

Abstract

Cells respond to a myriad of stressors by senescing, acquiring stable growth arrest, morphologic and metabolic changes, and a senescence-associated-secretory-phenotype (SASP). The heterogeneity of senescent cells (SnCs) and their SASP is vast, yet poorly characterized. SnCs have diverse roles in health and disease and are therapeutically targetable, making characterization of SnCs and harmonization of their nomenclature a priority. The Cellular Senescence Network (SenNet), a NIH Common Fund initiative, will leverage emerging single cell and spatial-omics to identify and map SnCs in numerous organs across the lifespan of humans and mice. A common coordinate framework will integrate the data, using validated, standardized methods, creating public 4-dimensional SnC atlases. Key SenNet deliverables include development of innovative tools/technologies to detect SnCs, biomarker discovery, common annotations to describe SnCs and extensive public data sets. The goal is to comprehensively understand and map SnCs for diagnostic and therapeutic purposes to improve human health.

Keywords

Cellular Senescence Network; Normal Aging; Senescence; Senescence-associated secretory phenotype; SenNet

Subject

LIFE SCIENCES, Cell & Developmental Biology

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