Jaroenlapnopparat, A.; Suppakitjanusant, P.; Ponvilawan, B.; Charoenngam, N. Vitamin D-Related Genetic Variations and Nonalcoholic Fatty Liver Disease: A Systematic Review. Int. J. Mol. Sci.2022, 23, 9122.
Jaroenlapnopparat, A.; Suppakitjanusant, P.; Ponvilawan, B.; Charoenngam, N. Vitamin D-Related Genetic Variations and Nonalcoholic Fatty Liver Disease: A Systematic Review. Int. J. Mol. Sci. 2022, 23, 9122.
Jaroenlapnopparat, A.; Suppakitjanusant, P.; Ponvilawan, B.; Charoenngam, N. Vitamin D-Related Genetic Variations and Nonalcoholic Fatty Liver Disease: A Systematic Review. Int. J. Mol. Sci.2022, 23, 9122.
Jaroenlapnopparat, A.; Suppakitjanusant, P.; Ponvilawan, B.; Charoenngam, N. Vitamin D-Related Genetic Variations and Nonalcoholic Fatty Liver Disease: A Systematic Review. Int. J. Mol. Sci. 2022, 23, 9122.
Abstract
Background: Studies have demonstrated the link between vitamin D-related genetic variations and non-skeletal outcomes. We aimed to identify all available data on the association of vitamin D-related genetic variations with non-alcoholic fatty liver disease (NAFLD).
Methods: Potentially eligible studies were identified from Embase and Medline databases from inception to June 2022 using search strategy that comprised terms for “Vitamin D” and “NAFLD”. Eligible study must report the association between vitamin D-related genetic variations and presence, severity or response to treatment of NAFLD. Data were extracted from each eligible study.
Results: A total of 3,495 articles were identified. After systematic review, twelve studies were in-cluded. A total of 26 genetic variations were identified. Presence of NAFLD was associated with variations of GC (rs222054, rs222020, rs10011000, rs7041), VDR (rs2228570, rs11168287, rs10783219, rs4752), CYP24A1 (rs3787557, rs6068816, rs2296241, rs2248359) and CYP27B1 (rs4646536). Severity of NAFLD was associated with variations of GC (rs4588), VDR (rs2228570, rs4334089), CYP2R1 (rs10741657), DHCR7 (rs1544410, rs3829251, rs12785878) and CYP24A1 (rs3787557, rs6068816, rs6097809, rs6127119, rs2248359, rs3787554, rs4809960, rs6022999). Response to calcitriol treatment was associated with variation of VDR (rs10735810).
Conclusions: Multiple vitamin D-related genetic variations were associated with NAFLD, indi-cating the role of vitamin D in the pathogenesis of NAFLD.
Medicine and Pharmacology, Gastroenterology and Hepatology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
