Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

SARS-CoV-2 Intermittent Virulence as A Result of Natural Selection

Version 1 : Received: 2 July 2022 / Approved: 4 July 2022 / Online: 4 July 2022 (10:28:04 CEST)

A peer-reviewed article of this Preprint also exists.

Rubio-Casillas, A.; Redwan, E.M.; Uversky, V.N. SARS-CoV-2 Intermittent Virulence as a Result of Natural Selection. COVID 2022, 2, 1089-1101. Rubio-Casillas, A.; Redwan, E.M.; Uversky, V.N. SARS-CoV-2 Intermittent Virulence as a Result of Natural Selection. COVID 2022, 2, 1089-1101.

Journal reference: COVID 2022, 2, 80
DOI: 10.3390/covid2080080

Abstract

For the first time in history, we have witnessed the origin and development of a pandemic. To handle the accelerated accumulation of viral mutations and to comprehend the virus' evolutionary adaptation in humans, an unparalleled program of genetic sequencing and monitoring of SARS-CoV-2 variants has been undertaken. Several scientists have theorized that, with the Omicron surge producing a more contagious but less severe disease, the end of COVID-19 is near. However, by analyzing the behavior shown by this virus for 2 years, we have noted that pandemic viruses do not always show a decreased virulence. Instead, it appears there is an evolutionary equilibrium between transmissibility and virulence. We have termed this concept “intermittent virulence”. The present work analyzes the temporal and epidemiological behavior of SARS-CoV-2 and suggests that there is a high possibility that new virulent variants will arise in the near future, although it is improbable that SARS-CoV-2´s virulence will be the same as was seen during the pandemic phase.

Keywords

SARS-CoV-2; Omicron; variant of concern

Subject

MEDICINE & PHARMACOLOGY, Other

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