Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

3,4-Dihydro-2(1H)-Pyridones as Building Blocks of Synthetic Relevance

Sisa Chalán-Gualán
ORCID logo ,
Vida Castro
,
Ruth Oropeza
,
Margarita Suárez
,
Fernando Albericio
* ORCID logo ,
Hortensia Rodríguez
* ORCID logo
Version 1 : Received: 28 June 2022 / Approved: 30 June 2022 / Online: 30 June 2022 (06:11:45 CEST)

A peer-reviewed article of this Preprint also exists.

Chalán-Gualán, S.; Castro, V.; Oropeza, R.; Suárez, M.; Albericio, F.; Rodríguez, H. 3,4-Dihydro-2(1H)-Pyridones as Building Blocks of Synthetic Relevance. Molecules 2022, 27, 5070. Chalán-Gualán, S.; Castro, V.; Oropeza, R.; Suárez, M.; Albericio, F.; Rodríguez, H. 3,4-Dihydro-2(1H)-Pyridones as Building Blocks of Synthetic Relevance. Molecules 2022, 27, 5070.

Abstract

3,4-Dihydro-2(1H)-pyridones (3,4-DHPo) and their derivatives are privileged structures present in natural products, which has been increased its relevance due to its biological activity in front of a broad range of targets, but especially for its importance as synthetic precursors of a variety of compounds with marked biological activity. Taking into account the large number of contributions published over the years regarding this kind of heterocycle, here we presented a current view of 3,4-dihydro-2(1H)-pyridones (3,4-DHPo), which include general aspects such as those related to nomenclature, synthesis, and biological activity; but also highlighting the importance of DHPo as building blocks of other relevance structures.

Keywords

3,4-DHPo; 1,4-DHPs; multicomponent reaction; non-conventional synthesis; synthetic precursors

Subject

Chemistry and Materials Science, Organic Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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