Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Revisiting Regulated Cell Death Responses in Viral Infection

Version 1 : Received: 4 June 2022 / Approved: 7 June 2022 / Online: 7 June 2022 (10:09:11 CEST)

A peer-reviewed article of this Preprint also exists.

Rex, D.A.B.; Keshava Prasad, T.S.; Kandasamy, R.K. Revisiting Regulated Cell Death Responses in Viral Infections. Int. J. Mol. Sci. 2022, 23, 7023. Rex, D.A.B.; Keshava Prasad, T.S.; Kandasamy, R.K. Revisiting Regulated Cell Death Responses in Viral Infections. Int. J. Mol. Sci. 2022, 23, 7023.

Journal reference: Int. J. Mol. Sci. 2022, 23, 7023
DOI: 10.3390/ijms23137023

Abstract

The fate of a viral infection in the host begins with various types of cellular responses, such as abortive, productive, latent, and destructive infections. Apoptosis, necroptosis, and pyroptosis are the three major types of regulated cell death mechanisms that play critical roles in viral infection response. Cell shrinkage, nuclear condensation, bleb formation, and retained membrane integrity are all signs of osmotic imbalance-driven cytoplasmic swelling and early membrane damage in necroptosis and pyroptosis. Caspase-driven apoptotic cell demise is considered in many circum-stances as an anti-inflammatory, and some pathogens hijack the cell death signaling routes to initiate a targeted attack against the host. In this review, we selected mechanisms by which viruses interfere with cell death are discussed in-depth and are used to illustrate the general principles and cellular signaling mechanisms of virus-host specific molecule interactions.

Keywords

cell death; death receptors; viral infection; signaling; regulated cell death

Subject

LIFE SCIENCES, Immunology

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