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CARDIOSIM©: The First Italian Software Platform for Simulation of the Cardiovascular System and Mechanical Circulatory and Ventilatory Support
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Version 1
: Received: 2 June 2022 / Approved: 7 June 2022 / Online: 7 June 2022 (09:07:19 CEST)
A peer-reviewed article of this Preprint also exists.
De Lazzari, B.; Badagliacca, R.; Filomena, D.; Papa, S.; Vizza, C.D.; Capoccia, M.; De Lazzari, C. CARDIOSIM© : The First Italian Software Platform for Simulation of the Cardiovascular System and Mechanical Circulatory and Ventilatory Support. Bioengineering 2022 , 9 , 383.
De Lazzari, B.; Badagliacca, R.; Filomena, D.; Papa, S.; Vizza, C.D.; Capoccia, M.; De Lazzari, C. CARDIOSIM©: The First Italian Software Platform for Simulation of the Cardiovascular System and Mechanical Circulatory and Ventilatory Support. Bioengineering 2022, 9, 383.
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De Lazzari, B.; Badagliacca, R.; Filomena, D.; Papa, S.; Vizza, C.D.; Capoccia, M.; De Lazzari, C. CARDIOSIM© : The First Italian Software Platform for Simulation of the Cardiovascular System and Mechanical Circulatory and Ventilatory Support. Bioengineering 2022 , 9 , 383.
De Lazzari, B.; Badagliacca, R.; Filomena, D.; Papa, S.; Vizza, C.D.; Capoccia, M.; De Lazzari, C. CARDIOSIM©: The First Italian Software Platform for Simulation of the Cardiovascular System and Mechanical Circulatory and Ventilatory Support. Bioengineering 2022, 9, 383.
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Abstract
This review is devoted to present the history of CARDIOSIM© software simulator platform, which was developed in Italy to simulate the human cardiovascular and respiratory system. The first version of CARDIOSIM© was developed at the Institute of Biomedical Technologies of the National Research Council in Rome. The first platform version published in 1991 ran on PC with disk operating system (MS-DOS) and was developed using the Turbo Basic language. The last version runs on PC with Microsoft Windows 10 operating system; it is implemented in Visual Basic and C++ languages. The platform has a modular structure consisting of seven different general sections, which can be assembled to reproduce different pathophysiological conditions. The software simulator can reproduce the most important circulatory phenomena in terms of pressure and volume relationships. It represents the whole circulation using a lumped-parameter model and enables the simulation of different cardiovascular conditions according to Starling’s law of the heart and a modified time-varying elastance model. Different mechanical ventilatory and circulatory devices have been implemented in the platform including thoracic artificial lung, ECMO, IABP, pulsatile and continuous right and left ventricular assist devices, biventricular pacemaker and biventricular assist devices. CARDIOSIM© is used in clinical and educational environment.
Keywords
CARDIOSIM©; numerical simulator; lumped parameter model; e-learning; mechanical circulatory support; ventilatory; cardiovascular system; heart failure; clinician
Subject
Computer Science and Mathematics, Software
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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