Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Urinary Sodium Excretion Enhances the Effect of Alcohol on Blood Pressure

Version 1 : Received: 20 May 2022 / Approved: 30 May 2022 / Online: 30 May 2022 (03:34:20 CEST)

A peer-reviewed article of this Preprint also exists.

Jiang, X.; Anasanti, M.D.; Drenos, F.; Blakemore, A.I.; Pazoki, R. Urinary Sodium Excretion Enhances the Effect of Alcohol on Blood Pressure. Healthcare 2022, 10, 1296. Jiang, X.; Anasanti, M.D.; Drenos, F.; Blakemore, A.I.; Pazoki, R. Urinary Sodium Excretion Enhances the Effect of Alcohol on Blood Pressure. Healthcare 2022, 10, 1296.

Journal reference: Healthcare 2022, 10, 1296
DOI: 10.3390/healthcare10071296

Abstract

Abstract Background: Alcohol consumption is linked to urinary sodium excretion and both of these traits are linked to hypertension and cardiovascular diseases (CVDs). The interplay between alcohol consumption and sodium on hypertension, and cardiovascular diseases (CVDs) is not well-described. Here, we used genetically predicted alcohol consumption and explored relationships between alcohol consumption, urinary sodium, hypertension, and CVDs. Methods: We performed a comparative analysis among 295,189 participants from the prospective cohort of the UK Biobank (baseline data collected between 2006 and 2010). We created a genetic risk score (GRS) using 105 published genetic variants in Europeans that were associated with alcohol consumption. We explored relationships between GRS, alcohol consumption, urinary sodium, blood pressure traits, and incident CVD. We used linear, logistic regression and Cox proportional hazards (PH) models in our analysis. Results: Our analyses supported an interaction effect between alcohol GRS and urinary sodium on hypertension (P interaction =0.03) and CVD (P interaction =0.03). In presence of high urinary sodium excretion, alcohol GRS increases blood pressure in a more enhanced fashion. Conclusions: Our results show that decrease in urinary sodium excretion offsets the risk posed by genetic risk of alcohol consumption.

Keywords

genetics of alcohol; urinary sodium; cardiovascular traits

Subject

MEDICINE & PHARMACOLOGY, Nutrition

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