Version 1
: Received: 26 May 2022 / Approved: 27 May 2022 / Online: 27 May 2022 (08:41:42 CEST)
How to cite:
Frediansyah, A.; Sallam, M.; Yufika, A.; Sharun, K.; Iqhrammullah, M.; Chandran, D.; Mamada, S.S.; Sallam, D.E.; Khader, Y.; Lemu, Y.K.; Yusuf, F.; Kretchy, J.; Abdeen, Z.; Torres-Roman, J.S.; Acharya, Y.; Bondarenko, A.; Ikram, A.; Jamil, K.F.; Kotfis, K.; Koyanagi, A.; Smith, L.; Megawati, D.; Rademaker, M.; Memish, Z.A.; Vento, S.; Nainu, F.; Harapan, H. Acute Severe Hepatitis of Unknown Etiology in Children: A Mini-Review. Preprints.org2022, 2022050370. https://doi.org/10.20944/preprints202205.0370.v1.
Frediansyah, A.; Sallam, M.; Yufika, A.; Sharun, K.; Iqhrammullah, M.; Chandran, D.; Mamada, S.S.; Sallam, D.E.; Khader, Y.; Lemu, Y.K.; Yusuf, F.; Kretchy, J.; Abdeen, Z.; Torres-Roman, J.S.; Acharya, Y.; Bondarenko, A.; Ikram, A.; Jamil, K.F.; Kotfis, K.; Koyanagi, A.; Smith, L.; Megawati, D.; Rademaker, M.; Memish, Z.A.; Vento, S.; Nainu, F.; Harapan, H. Acute Severe Hepatitis of Unknown Etiology in Children: A Mini-Review. Preprints.org 2022, 2022050370. https://doi.org/10.20944/preprints202205.0370.v1.
Cite as:
Frediansyah, A.; Sallam, M.; Yufika, A.; Sharun, K.; Iqhrammullah, M.; Chandran, D.; Mamada, S.S.; Sallam, D.E.; Khader, Y.; Lemu, Y.K.; Yusuf, F.; Kretchy, J.; Abdeen, Z.; Torres-Roman, J.S.; Acharya, Y.; Bondarenko, A.; Ikram, A.; Jamil, K.F.; Kotfis, K.; Koyanagi, A.; Smith, L.; Megawati, D.; Rademaker, M.; Memish, Z.A.; Vento, S.; Nainu, F.; Harapan, H. Acute Severe Hepatitis of Unknown Etiology in Children: A Mini-Review. Preprints.org2022, 2022050370. https://doi.org/10.20944/preprints202205.0370.v1.
Frediansyah, A.; Sallam, M.; Yufika, A.; Sharun, K.; Iqhrammullah, M.; Chandran, D.; Mamada, S.S.; Sallam, D.E.; Khader, Y.; Lemu, Y.K.; Yusuf, F.; Kretchy, J.; Abdeen, Z.; Torres-Roman, J.S.; Acharya, Y.; Bondarenko, A.; Ikram, A.; Jamil, K.F.; Kotfis, K.; Koyanagi, A.; Smith, L.; Megawati, D.; Rademaker, M.; Memish, Z.A.; Vento, S.; Nainu, F.; Harapan, H. Acute Severe Hepatitis of Unknown Etiology in Children: A Mini-Review. Preprints.org 2022, 2022050370. https://doi.org/10.20944/preprints202205.0370.v1.
Abstract
The emergence of acute, severe non hepA–E hepatitis of unknown etiology (ASHUE) has attracted global concern owing to the very young age of the patients and its unknown etiology. Although this condition has been linked to several possible causes, including viral infection, drugs, and/or toxin exposure, the exact cause remains unknown; this makes treatment recommendations very difficult. In this review, we summarize recent updates on the clinical manifestations, complemented with laboratory results, case numbers with the global distribution and other epidemiological characteristics, and the possible etiologies. We also provide the proposed actions that could be undertaken to control and prevent further spread of this hepatitis. Since many etiological and pathological aspects of the acute non hepA–E hepatitis remain unclear, further research is needed to minimize the severe impact of this disease.
Keywords
Acute non hepA–E hepatitis; clinical manifestations; epidemiological characteristics; prevention
Subject
Biology and Life Sciences, Virology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter:
The commenter has declared there is no conflict of interests.