Acute Severe Hepatitis of Unknown Etiology in Children: A Mini-Review

Andri Frediansyah; Malik Sallam; Amanda Yufika; Khan Sharun; Muhammad Iqhrammullah; Deepak Chandran; Sukamto S. Mamada; Dina E. Sallam; Yousef Khader; Yohannes K. Lemu; Fauzi Yusuf; James-Paul Kretchy; Ziad Abdeen; J. S. Torres-Roman; Yogesh Acharya; Anastasia Bondarenko; Aamer Ikram; Kurnia F. Jamil; Katarzyna Kotfis; Ai Koyanagi; Lee Smith; Dewi Megawati; Marius Rademaker; Ziad A. Memish; Sandro Vento; Firzan Nainu; Harapan Harapan

doi:10.20944/preprints202205.0370.v1

How to cite: Frediansyah, A.; Sallam, M.; Yufika, A.; Sharun, K.; Iqhrammullah, M.; Chandran, D.; Mamada, S.S.; Sallam, D.E.; Khader, Y.; Lemu, Y.K.; Yusuf, F.; Kretchy, J.; Abdeen, Z.; Torres-Roman, J.S.; Acharya, Y.; Bondarenko, A.; Ikram, A.; Jamil, K.F.; Kotfis, K.; Koyanagi, A.; Smith, L.; Megawati, D.; Rademaker, M.; Memish, Z.A.; Vento, S.; Nainu, F.; Harapan, H. Acute Severe Hepatitis of Unknown Etiology in Children: A Mini-Review. Preprints 2022, 2022050370. https://doi.org/10.20944/preprints202205.0370.v1 Frediansyah, A.; Sallam, M.; Yufika, A.; Sharun, K.; Iqhrammullah, M.; Chandran, D.; Mamada, S.S.; Sallam, D.E.; Khader, Y.; Lemu, Y.K.; Yusuf, F.; Kretchy, J.; Abdeen, Z.; Torres-Roman, J.S.; Acharya, Y.; Bondarenko, A.; Ikram, A.; Jamil, K.F.; Kotfis, K.; Koyanagi, A.; Smith, L.; Megawati, D.; Rademaker, M.; Memish, Z.A.; Vento, S.; Nainu, F.; Harapan, H. Acute Severe Hepatitis of Unknown Etiology in Children: A Mini-Review. Preprints 2022, 2022050370. https://doi.org/10.20944/preprints202205.0370.v1

Abstract

The emergence of acute, severe non hepA–E hepatitis of unknown etiology (ASHUE) has attracted global concern owing to the very young age of the patients and its unknown etiology. Although this condition has been linked to several possible causes, including viral infection, drugs, and/or toxin exposure, the exact cause remains unknown; this makes treatment recommendations very difficult. In this review, we summarize recent updates on the clinical manifestations, complemented with laboratory results, case numbers with the global distribution and other epidemiological characteristics, and the possible etiologies. We also provide the proposed actions that could be undertaken to control and prevent further spread of this hepatitis. Since many etiological and pathological aspects of the acute non hepA–E hepatitis remain unclear, further research is needed to minimize the severe impact of this disease.

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Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Comment 1

Received: 10 June 2022
Commenter:

Harapan Harapan

The commenter has declared there is no conflict of interests.

Comment: The published version of this preprint can be accessed here: https://narraj.org/main/issue/view/7

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Acute Severe Hepatitis of Unknown Etiology in Children: A Mini-Review

Abstract

Keywords

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