Li, K.; Zhang, Y.; Wang, Y.; Guo, X.; Dai, X.; Song, L. The LncRNA Prostate Androgen-Regulated Transcript 1 (PART-1) Promotes Non-Small Cell Lung Cancer Progression by Regulating the MiR-204-3p/IGFBP-2 Pathway. Journal of Laboratory Medicine 2023, 47, 31–40, doi:10.1515/labmed-2022-0082.
Li, K.; Zhang, Y.; Wang, Y.; Guo, X.; Dai, X.; Song, L. The LncRNA Prostate Androgen-Regulated Transcript 1 (PART-1) Promotes Non-Small Cell Lung Cancer Progression by Regulating the MiR-204-3p/IGFBP-2 Pathway. Journal of Laboratory Medicine 2023, 47, 31–40, doi:10.1515/labmed-2022-0082.
Li, K.; Zhang, Y.; Wang, Y.; Guo, X.; Dai, X.; Song, L. The LncRNA Prostate Androgen-Regulated Transcript 1 (PART-1) Promotes Non-Small Cell Lung Cancer Progression by Regulating the MiR-204-3p/IGFBP-2 Pathway. Journal of Laboratory Medicine 2023, 47, 31–40, doi:10.1515/labmed-2022-0082.
Li, K.; Zhang, Y.; Wang, Y.; Guo, X.; Dai, X.; Song, L. The LncRNA Prostate Androgen-Regulated Transcript 1 (PART-1) Promotes Non-Small Cell Lung Cancer Progression by Regulating the MiR-204-3p/IGFBP-2 Pathway. Journal of Laboratory Medicine 2023, 47, 31–40, doi:10.1515/labmed-2022-0082.
Abstract
Lung cancer is a common malignant tumor of the lung and the leading cause of cancer mortality worldwide. Non-small-cell lung cancer (NSCLC) accounts for 80%–85% of lung cancer, 40% of NSCLCs will have spread beyond the lungs by the time it is diagnosed. Long non-coding RNA (LncRNA) prostate androgen-regulated transcript 1 (PART-1) was reported that promote the development of several cancers. In the current study, we conducted experiments to investigate the role of PART-1 in the proliferation, invasion, and migration of NSCLC. The expression level of the PART-1 gene increased significantly in the NSCLC cell lines, including A549, H1229, H1650, H1975, and PC9. Knocking down of PART-1 inhibited the proliferation, invasion, and migration of A549 cells, moreover, decreased the tumor proliferation in nude mice. We confirmed that PART-1 targeted miR-204-3p directly, and miR-204-3p targeted the insulin-like growth factor binding protein 2 (IGFBP-2) directly. Furthermore, we discovered that PART-1 involved the NSCLC progression by regulating the miR-204-3p-targeted IGFBP-2 pathway. LncRNA PART-1 might be a target for treating NSCLC, and a warning sign of diagnosis of early lung cancer.
Keywords
Long non-coding RNA; Prostate androgen-regulated transcript 1; miR-204-3p; insulin-like growth factor binding protein 2
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
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