Preprint Communication Version 1 Preserved in Portico This version is not peer-reviewed

Variant Allele of ALDH2, rs671 Associates with Attenuated Post-Vaccination Response in Anti-SARS-CoV-2 Spike Protein IgG: A Prospective Study in the Japanese General Population

Version 1 : Received: 20 May 2022 / Approved: 24 May 2022 / Online: 24 May 2022 (10:08:35 CEST)

How to cite: Matsumoto, A.; Hara, M.; Ashenagar, M.S.; Tokiya, M.; Sawada, T.; Iwasaka, C.; Furukawa, T.; Kitagawa, K.; Miyake, Y.; Hirota, Y. Variant Allele of ALDH2, rs671 Associates with Attenuated Post-Vaccination Response in Anti-SARS-CoV-2 Spike Protein IgG: A Prospective Study in the Japanese General Population. Preprints 2022, 2022050330 (doi: 10.20944/preprints202205.0330.v1). Matsumoto, A.; Hara, M.; Ashenagar, M.S.; Tokiya, M.; Sawada, T.; Iwasaka, C.; Furukawa, T.; Kitagawa, K.; Miyake, Y.; Hirota, Y. Variant Allele of ALDH2, rs671 Associates with Attenuated Post-Vaccination Response in Anti-SARS-CoV-2 Spike Protein IgG: A Prospective Study in the Japanese General Population. Preprints 2022, 2022050330 (doi: 10.20944/preprints202205.0330.v1).

Abstract

Uncovering the predictors of vaccine immunogenicity is essential for infection control. We have reported that the most prevalent polymorphism of the aldehyde dehydrogenase 2 (ALDH2) gene, rs671, may be associated with an attenuated immune system. To test the inverse relation between rs671 and antibody production after COVID-19 vaccination, the levels of anti-SARS-CoV-2 Spike protein S1 subunit (S1) IgG were repeatedly measured for four months before and after vaccination with BNT162b2 or mRNA-1273, in 88 Japanese workers and students (including 45 females, aged 21–56 years, with an rs671 variant allele frequency of 0.3). The mixed model including fixed effects of the vaccine type, weeks post vaccination (categorical variable), sex, age, body height, smoking status, ethanol intake, exercise habit, perceived stress, steroid use, allergic diseases, and dyslipidemia, indicated an inverse association between log-transformed anti-S1 IgG levels and the number of rs671 variant alleles (partial regression coefficient = -0.15, p = 0.002). Our study indicated for the first time that the variant allele of ALDH2, rs671, is associated with the attenuated immunogenicity of COVID-19 mRNA vaccines. Our finding may provide a basis for personalized disease prevention based on a genetic polymorphism that is prevalent among East Asians.

Keywords

ALDH2; rs671; COVID-19; vaccine; immunogenicity

Subject

MEDICINE & PHARMACOLOGY, Other

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