Neuroprotective and Anti-Epileptic Potentials of Genus Artemisia L.

Bayan Sailike; Wei-Lin Jin; Sholpan Askarova; Altynay Adilbayeva; Janar Jenis; Burkitkan Akbay; Zhannur Omarova; Tursonjan Tokay

doi:10.20944/preprints202205.0293.v1

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preprints.org > biology > physiology > doi: 10.20944/preprints202205.0293.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Neuroprotective and Anti-Epileptic Potentials of Genus Artemisia L.

Version 1 : Received: 20 May 2022 / Approved: 23 May 2022 / Online: 23 May 2022 (10:20:52 CEST)

How to cite: Sailike, B.; Jin, W.; Askarova, S.; Adilbayeva, A.; Jenis, J.; Akbay, B.; Omarova, Z.; Tokay, T. Neuroprotective and Anti-Epileptic Potentials of Genus Artemisia L. . Preprints 2022, 2022050293. https://doi.org/10.20944/preprints202205.0293.v1. Sailike, B.; Jin, W.; Askarova, S.; Adilbayeva, A.; Jenis, J.; Akbay, B.; Omarova, Z.; Tokay, T. Neuroprotective and Anti-Epileptic Potentials of Genus Artemisia L. . Preprints 2022, 2022050293. https://doi.org/10.20944/preprints202205.0293.v1.

Cite as:

Sailike, B.; Jin, W.; Askarova, S.; Adilbayeva, A.; Jenis, J.; Akbay, B.; Omarova, Z.; Tokay, T. Neuroprotective and Anti-Epileptic Potentials of Genus Artemisia L. . Preprints 2022, 2022050293. https://doi.org/10.20944/preprints202205.0293.v1. Sailike, B.; Jin, W.; Askarova, S.; Adilbayeva, A.; Jenis, J.; Akbay, B.; Omarova, Z.; Tokay, T. Neuroprotective and Anti-Epileptic Potentials of Genus Artemisia L. . Preprints 2022, 2022050293. https://doi.org/10.20944/preprints202205.0293.v1.

Abstract

Epilepsy is a chronic neuronal disorder characterized by periodic, unpredictable, and recurrent seizures due to either a genetically determined or an acquired brain disorder. Although many anti-epileptics drugs (AEDs) are developed to control epilepsy, 30% of patients still need additional drugs or experience recurrent seizures and psychiatric and behavioral side effects. Thus, the need for medical care for patients with uncontrolled epilepsy remains unmet. The Genus Artemisia L. is one of the largest genera in the Asteraceae family with more than 500 species widely distributed in Europe, Asia, and North America. Many Artemisia species have been used in various treatments since ancient times as folk remedies. They demonstrated strong antioxidant, anti-inflammatory, antimicrobial, antimalarial, and antitumor activity. Recent studies reveal that some species of Artemisia demonstrated a therapeutic benefit for epilepsy by its anti-oxidant, anti-inflammatory, neuroprotective, and anticonvulsant properties. In this review, we investigate the current state of the literature regarding the neuroprotective and antiepileptic potentials of the genus Artemisia and its possible underlying mechanisms.

Keywords

Genus Artemisia; anticonvulsant; antioxidant; antiapoptosis; anti-neuroinflammatory; neuropro-tective; cognitive function

Subject

BIOLOGY, Physiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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