Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Synthesis of Magnetic Bioactive Composites Thought Bio-Inspired Surface Modification

Version 1 : Received: 5 May 2022 / Approved: 9 May 2022 / Online: 9 May 2022 (13:47:08 CEST)

A peer-reviewed article of this Preprint also exists.

Volov, A.; Shkodenko, L.; Koshel, E.; Drozdov, A.S. Bio-Inspired Surface Modification of Magnetite Nanoparticles with Dopamine Conjugates. Nanomaterials 2022, 12, 2230. Volov, A.; Shkodenko, L.; Koshel, E.; Drozdov, A.S. Bio-Inspired Surface Modification of Magnetite Nanoparticles with Dopamine Conjugates. Nanomaterials 2022, 12, 2230.

Abstract

Organically-coated nanomaterials are intensively studied and find numerous applications in a wide range of areas ranging from optics to biomedicine. One of the recent trends in material science is the application of bio-mimetic polydopamine coatings that can be produced on a variety of substrates in a cost-efficient way under mild conditions. Such coatings not only modify the biocompatibility of the material but also add functional amino groups to the surface that can be further modified by classic conjugation techniques. Here we show an alternative strategy of substrates modification using not dopamine but dopamine conjugates. Compared to the classic scheme the proposed strategy allows for separation of the "organic" and "colloidal" stages and simplifies identification and purification steps. Modification with pre-modified dopamine allowed to achieve high active components loading up to 10.5% wt. A series of organo-inorganic hybrids were synthesized and their bioactivity was analyzed.

Keywords

magnetite; dopamine; surface modification; hybrid materials; antibacterial agents.

Subject

Chemistry and Materials Science, Physical Chemistry

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