Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Tetracyclines - An Important Therapeutic Tool for Dermatologist

Version 1 : Received: 28 April 2022 / Approved: 6 May 2022 / Online: 6 May 2022 (03:34:44 CEST)

A peer-reviewed article of this Preprint also exists.

Orylska-Ratynska, M.; Placek, W.; Owczarczyk-Saczonek, A. Tetracyclines—An Important Therapeutic Tool for Dermatologists. Int. J. Environ. Res. Public Health 2022, 19, 7246. Orylska-Ratynska, M.; Placek, W.; Owczarczyk-Saczonek, A. Tetracyclines—An Important Therapeutic Tool for Dermatologists. Int. J. Environ. Res. Public Health 2022, 19, 7246.

Journal reference: Int. J. Environ. Res. Public Health 2022, 19, 7246
DOI: 10.3390/ijerph19127246

Abstract

Tetracyclines are a group of antibiotics whose first representative was discovered over 70 years ago. Since then, they have been of great interest in dermatology. In addition to their antibacterial activity, they are able to inhibit metalloproteinases and exhibit anti-inflammatory, anti-apoptotic and antioxidant effects. The side effects have been thoroughly studied over the years. The most characteristic and important in daily dermatolgical practice are: phototoxicity, hyperpigmentation, onycholysis, photoonycholysis, induced lupus erythematosus, idiopathic intracranial hypertension. In this article, we summarize the use of tetracyclines in infectious diseases and inflammatory dermatoses, and further discuss indications where the efficacy and safety of tetracyclines have been highlighted over the past few years.

Keywords

tetracyclines; doxycycline; limecycline; minocycline; pleiotrophy; non-antibiotic properties

Subject

MEDICINE & PHARMACOLOGY, Dermatology

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