Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Biochemical and Metabolomic Responses of Antarctic Bacterium Planococcus sp. O5 Induced by Copper Ion

Version 1 : Received: 26 April 2022 / Approved: 28 April 2022 / Online: 28 April 2022 (03:59:23 CEST)

How to cite: Cheng, Z.; Shi, C.; Gao, X.; Wang, X.; Kan, G. Biochemical and Metabolomic Responses of Antarctic Bacterium Planococcus sp. O5 Induced by Copper Ion. Preprints 2022, 2022040269 (doi: 10.20944/preprints202204.0269.v1). Cheng, Z.; Shi, C.; Gao, X.; Wang, X.; Kan, G. Biochemical and Metabolomic Responses of Antarctic Bacterium Planococcus sp. O5 Induced by Copper Ion. Preprints 2022, 2022040269 (doi: 10.20944/preprints202204.0269.v1).

Abstract

Copper toxicity has been a selective pressure on the sea-ice bacteria due to its widespread occur-rence in Antarctica. Here, with a combined biochemical and metabolomic approach, the Cu2+ ad-aptation mechanisms of Antarctic bacteria were analyzed. Heavy metal resistance pattern of Pb2+ > Cu2+ > Cd2+ > Hg2+ > Zn2+ was observed. Copper treatment did increase the activity of antioxidants and enzymes, maintaining cellular redox state balance and normal cell division and growth. Metabolomics analysis demonstrated that fatty acids, amino acids, and carbohydrates played dominant roles in copper stress adaptation. The results indicated that the adaptation mechanisms of strain O5 to copper stress included protein synthesis and repair, accumulation of organic per-meable substances, up-regulation of energy metabolism, and formation of fatty acids. This study increases the resistance mechanism understanding of Antarctic strains to heavy metals in extreme environments.

Keywords

Antarctic strain; copper stress; adaption responses; metabolomics

Subject

BIOLOGY, Ecology

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