Gu, P.; Pu, B.; Li, S.; Tan, N.; Luo, L.; Feng, J.; Zeng, Z.; Zheng, X. Causal Effects of Tea Intake on Multiple Types of Fractures: A Two-Sample Mendelian Randomization Study. Preprints2022, 2022040256. https://doi.org/10.20944/preprints202204.0256.v1
APA Style
Gu, P., Pu, B., Li, S., Tan, N., Luo, L., Feng, J., Zeng, Z., & Zheng, X. (2022). Causal Effects of Tea Intake on Multiple Types of Fractures: A Two-Sample Mendelian Randomization Study. Preprints. https://doi.org/10.20944/preprints202204.0256.v1
Chicago/Turabian Style
Gu, P., ZhanPeng Zeng and XiaoHui Zheng. 2022 "Causal Effects of Tea Intake on Multiple Types of Fractures: A Two-Sample Mendelian Randomization Study" Preprints. https://doi.org/10.20944/preprints202204.0256.v1
Abstract
Fracture is a global public health disease. Bone health and fracture risk have become the focus of public and scientific attention. Observational studies have reported that tea consumption is associated with fracture risk, but the results are inconsistent. The present study was conducted to evaluate whether tea consumption was causally associated with the risk of bone fracture through two-sample Mendelian Randomization (MR) analysis. We included a large genome-wide association study (GWAS) associated with tea consumption of 447,485 individuals and analyzed the effects of genetic instruments on fractures using fracture cases from the UK Biobank dataset (n=361,194). Inverse variance weighted (IVW) indicated no causal effects of tea consumption on fractures of the skull and face, shoulder and upper arm, hand and wrist, femur, calf, and ankle (odds ratio=1.000, P=0.881; OR=1.000, P=0.857; OR=1.002, P=0.339; OR=0.997, P=0.054; OR=0.998, P=0.569, respectively). Consistent results were also found in MR-Egger, weighted median, and weighted mode. Our research provided evidence that tea consumption is unlikely to affect the incidence of fractures.
Keywords
tea intake; fracture; Mendelian randomization; genome-wide association studies
Subject
Biology and Life Sciences, Food Science and Technology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
