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How to Heal the Gut’s Brain: Regeneration of the Enteric Nervous System
Version 1
: Received: 31 March 2022 / Approved: 9 April 2022 / Online: 9 April 2022 (01:49:53 CEST)
A peer-reviewed article of this Preprint also exists.
Rueckert, H.; Ganz, J. How to Heal the Gut’s Brain: Regeneration of the Enteric Nervous System. Int. J. Mol. Sci. 2022, 23, 4799. Rueckert, H.; Ganz, J. How to Heal the Gut’s Brain: Regeneration of the Enteric Nervous System. Int. J. Mol. Sci. 2022, 23, 4799.
Abstract
The neural-crest derived enteric nervous system (ENS) is the intrinsic nervous system of the gastrointestinal (GI) tract and controls all gut functions, including motility. Lack of ENS neurons causes various ENS disorders such as Hirschsprung Disease. One treatment option for ENS dis-orders includes the activation of resident stem cells to regenerate ENS neurons. Regeneration in the ENS has mainly been studied in mammalian species using surgical or chemically-induced injury methods. These mammalian studies showed a variety of regenerative responses with generally limited regeneration of ENS neurons, but (partial) regrowth and functional recovery of nerve fibers. Several aspects might contribute to the variety in regenerative responses, including observation time after injury, species, and gut region targeted. Zebrafish have recently emerged as a promising model system to study ENS regeneration as larvae possess the ability to generate new neurons after ablation. As the next steps in ENS regeneration research, we need a detailed under-standing of how regeneration is regulated on a cellular and molecular level both in animal models with high and low regenerative capacity. Understanding the regulatory programs necessary for robust ENS regeneration will pave the way for using neural regeneration as a therapeutic approach to treating ENS disorders.
Keywords
enteric progenitor cell; zebrafish; inflammation; Hirschsprung Disease; neural crest cell; ENS neuropathies
Subject
Biology and Life Sciences, Cell and Developmental Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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