Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Advances in the Developing of SARS-CoV-2 Mpro Inhibitors

Version 1 : Received: 27 March 2022 / Approved: 8 April 2022 / Online: 8 April 2022 (03:01:37 CEST)

A peer-reviewed article of this Preprint also exists.

Agost-Beltrán, L.; de la Hoz-Rodríguez, S.; Bou-Iserte, L.; Rodríguez, S.; Fernández-de-la-Pradilla, A.; González, F.V. Advances in the Development of SARS-CoV-2 Mpro Inhibitors. Molecules 2022, 27, 2523. Agost-Beltrán, L.; de la Hoz-Rodríguez, S.; Bou-Iserte, L.; Rodríguez, S.; Fernández-de-la-Pradilla, A.; González, F.V. Advances in the Development of SARS-CoV-2 Mpro Inhibitors. Molecules 2022, 27, 2523.

Abstract

Since the outbreak of COVID-19, one of the strategies used to search for new drugs has been to find inhibitors of the main protease (Mpro) of virus SARS-CoV-2. Initially, previously reported inhibitors of related proteases like the main proteases of SARS-CoV and MERS-CoV were tested. Then a huge effort has been done by the scientific community to design, synthesize and test new small molecules acting as inactivators of SARS-CoV-2 Mpro. From the structure view, these compounds can be classified into two main groups: one corresponds to modified peptides displaying an adequate sequence for high affinity and a reactive warhead, and the second one is a diverse group including chemical compounds which do not have a peptide framework. Although a drug including a SARS-CoV-2 main protease has already been commercialized, denoting the importance of this field, more compounds have been demonstrated to be promising potent inhibitors as potential antiviral drugs.

Keywords

COVID-19; Main protease; Mpro; inhibitors

Subject

Chemistry and Materials Science, Medicinal Chemistry

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.