Agost-Beltrán, L.; de la Hoz-Rodríguez, S.; Bou-Iserte, L.; Rodríguez, S.; Fernández-de-la-Pradilla, A.; González, F.V. Advances in the Development of SARS-CoV-2 Mpro Inhibitors. Molecules2022, 27, 2523.
Agost-Beltrán, L.; de la Hoz-Rodríguez, S.; Bou-Iserte, L.; Rodríguez, S.; Fernández-de-la-Pradilla, A.; González, F.V. Advances in the Development of SARS-CoV-2 Mpro Inhibitors. Molecules 2022, 27, 2523.
Agost-Beltrán, L.; de la Hoz-Rodríguez, S.; Bou-Iserte, L.; Rodríguez, S.; Fernández-de-la-Pradilla, A.; González, F.V. Advances in the Development of SARS-CoV-2 Mpro Inhibitors. Molecules2022, 27, 2523.
Agost-Beltrán, L.; de la Hoz-Rodríguez, S.; Bou-Iserte, L.; Rodríguez, S.; Fernández-de-la-Pradilla, A.; González, F.V. Advances in the Development of SARS-CoV-2 Mpro Inhibitors. Molecules 2022, 27, 2523.
Abstract
Since the outbreak of COVID-19, one of the strategies used to search for new drugs has been to find inhibitors of the main protease (Mpro) of virus SARS-CoV-2. Initially, previously reported inhibitors of related proteases like the main proteases of SARS-CoV and MERS-CoV were tested. Then a huge effort has been done by the scientific community to design, synthesize and test new small molecules acting as inactivators of SARS-CoV-2 Mpro. From the structure view, these compounds can be classified into two main groups: one corresponds to modified peptides displaying an adequate sequence for high affinity and a reactive warhead, and the second one is a diverse group including chemical compounds which do not have a peptide framework. Although a drug including a SARS-CoV-2 main protease has already been commercialized, denoting the importance of this field, more compounds have been demonstrated to be promising potent inhibitors as potential antiviral drugs.
Keywords
COVID-19; Main protease; Mpro; inhibitors
Subject
Chemistry and Materials Science, Medicinal Chemistry
Copyright:
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