Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Cannabis sativa CBD Extract Shows Promising Antibacterial Activity against S. typhimurium and S. newington

Version 1 : Received: 26 March 2022 / Approved: 28 March 2022 / Online: 28 March 2022 (14:30:09 CEST)

How to cite: Gildea, L.; Ayariga, J.; Ajayi, O.; Xu, J.; Villafane, R.; Samuel-Foo, M. Cannabis sativa CBD Extract Shows Promising Antibacterial Activity against S. typhimurium and S. newington. Preprints 2022, 2022030367 (doi: 10.20944/preprints202203.0367.v1). Gildea, L.; Ayariga, J.; Ajayi, O.; Xu, J.; Villafane, R.; Samuel-Foo, M. Cannabis sativa CBD Extract Shows Promising Antibacterial Activity against S. typhimurium and S. newington. Preprints 2022, 2022030367 (doi: 10.20944/preprints202203.0367.v1).

Abstract

Products derived from Cannabis sativa have gained increased interest and popularity. As these products become common amongst the public, the heath and potential therapeutic values associated with hemp have become a premier focus of research. While the psychoactive and medicinal properties of Cannabis products have been extensively highlighted in literature, the antibacterial properties of CBD have not been explored in depth. This research serves to examine the antibacterial potential of CBD against Salmonella newington and Salmonella typhimurium. In this study we observed bacterial response to CBD exposure through biological assays, bacterial kinetics, and fluorescence microscopy. Additionally, comparative studies between CBD and ampicillin were conducted against Salmonella typhimurium and Salmonella newington to determine comparative efficacy. Furthermore, we observed potential resistance development of our Salmonella spp. against CBD treatment.

Keywords

Salmonella; Novel Antibacterial Agents; Cannabinoids

Subject

LIFE SCIENCES, Microbiology

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