Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

In Vivo Renal Lipid Quantification by Accelerated Magnetic Resonance Spectroscopic Imaging at 3 T: Feasibility and Reliability Study

Ahmad A. Alhulail
* ORCID logo ,
Mahsa Servati
ORCID logo ,
Nathan Ooms
,
Oguz Akin
,
Alp Dincer
,
M. Albert Thomas
,
Ulrike Dydak
ORCID logo ,
Uzay E. Emir
* ORCID logo
Version 1 : Received: 16 March 2022 / Approved: 18 March 2022 / Online: 18 March 2022 (02:59:02 CET)

A peer-reviewed article of this Preprint also exists.

Alhulail, A.A.; Servati, M.; Ooms, N.; Akin, O.; Dincer, A.; Thomas, M.A.; Dydak, U.; Emir, U.E. In Vivo Renal Lipid Quantification by Accelerated Magnetic Resonance Spectroscopic Imaging at 3T: Feasibility and Reliability Study. Metabolites 2022, 12, 386. Alhulail, A.A.; Servati, M.; Ooms, N.; Akin, O.; Dincer, A.; Thomas, M.A.; Dydak, U.; Emir, U.E. In Vivo Renal Lipid Quantification by Accelerated Magnetic Resonance Spectroscopic Imaging at 3T: Feasibility and Reliability Study. Metabolites 2022, 12, 386.

Abstract

A reliable and practical renal-lipid quantification and imaging method is needed. Here, the feasibility of an accelerated MRSI method to map renal fat fractions (FF) at 3T and its repeatability were investigated. A 2D density-weighted concentric-ring-trajectory MRSI was used to accelerate acquiring 48×48 voxels (each of 0.25 ml spatial-resolution) without respiratory navigation implementations. The data was collected over 512 complex-FID timepoints with a 1250 Hz spectral bandwidth. The MRSI sequence was designed with a metabolite-cycling technique for lipid-water separation. The in vivo repeatability performance of the sequence was assessed by conducting a test-reposition-retest study within healthy subjects. The coefficient of variation (CV) in the estimated FF from the test-retest measurements showed a high degree of repeatability of the MRSI-FF (CV= 4.3 ±2.5%). Additionally, the matching level of spectral signature within the same anatomical region was also investigated, and their intrasubject repeatability was also high, with a small standard deviation (8.1 ±6.4%). The MRSI acquisition duration was ~3 minutes only. The proposed MRSI technique can be a reliable technique to quantify and map renal metabolites within a clinically acceptable scan time at 3T that supports the future application of this technique for the non-invasive characterization of heterogeneous renal diseases and tumors.

Keywords

kidney; renal; lipid; fast MRSI

Subject

Medicine and Pharmacology, Urology and Nephrology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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