Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Optimised Design of An Arterial Network Model Reproduces Characteristic Central and Peripheral Hemodynamic Waveform Features in Young Adults

Version 1 : Received: 15 March 2022 / Approved: 16 March 2022 / Online: 16 March 2022 (10:05:44 CET)

A peer-reviewed article of this Preprint also exists.

Kondiboyina, A.; Harrington, H.A.; Smolich, J.J.; Cheung, M.M.H.; Mynard, J.P. Optimized Design of an Arterial Network Model Reproduces Characteristic Central and Peripheral Haemodynamic Waveform Features of Young Adults. The Journal of Physiology 2022, 600, 3725–3747, doi:10.1113/jp282942. Kondiboyina, A.; Harrington, H.A.; Smolich, J.J.; Cheung, M.M.H.; Mynard, J.P. Optimized Design of an Arterial Network Model Reproduces Characteristic Central and Peripheral Haemodynamic Waveform Features of Young Adults. The Journal of Physiology 2022, 600, 3725–3747, doi:10.1113/jp282942.

Abstract

The arterial network in healthy young adults is thought to be structured to minimise wave reflection in conduit arteries, producing an ascending aortic pressure waveform with three key features: early systolic peak, negative systolic augmentation, and diastolic hump. One-dimensional computer models have provided significant insights into arterial haemodynamics, but no previous models of the young adult have exhibited these three features. Since the latter was likely to be related to unrepresentative or non-optimised impedance properties of the model arterial networks, we developed a new ‘YoungAdult’ model that incorporated 1) a novel and more accurate empirical equation for approximating wave speeds, based on area and relative distance to elastic-muscular arterial transition points, 2) optimally-matched arterial junctions, and 3) an improved arterial network geometry that eliminated ‘within-segment’ taper (which causes wave reflection in conduit arteries) whilst establishing ‘impedance-preserving’ taper. These model properties led to wave reflection occurring predominantly at distal vascular beds, rather than in conduit arteries. The model predicted all three typical characteristics of an ascending aortic pressure waveform observed in young adults. When compared with non-invasively acquired pressure and velocity measurements (obtained via tonometry and Doppler ultrasound in 7 young adults), the model was also shown to reproduce the typical waveform morphology observed in the radial, brachial, carotid, temporal, femoral, and tibial arteries. The YoungAdult model provides support for the concept that the arterial tree impedance in healthy young adults is exquisitely optimised, and it provides an important baseline model for investigating cardiovascular changes in ageing and disease states.

Keywords

cardiovascular modelling; arterial haemodynamics; wave reflection

Subject

Engineering, Bioengineering

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.