Version 1
: Received: 13 March 2022 / Approved: 15 March 2022 / Online: 15 March 2022 (14:20:57 CET)
Version 2
: Received: 8 April 2022 / Approved: 11 April 2022 / Online: 11 April 2022 (08:43:41 CEST)
Version 3
: Received: 11 July 2022 / Approved: 12 July 2022 / Online: 12 July 2022 (08:07:43 CEST)
Version 4
: Received: 16 September 2022 / Approved: 16 September 2022 / Online: 16 September 2022 (11:45:33 CEST)
Version 5
: Received: 27 June 2023 / Approved: 28 June 2023 / Online: 28 June 2023 (16:13:16 CEST)
Version 6
: Received: 26 August 2023 / Approved: 28 August 2023 / Online: 29 August 2023 (09:31:10 CEST)
How to cite:
Chen, S. Can Latency-Reversing Drugs Reawaken Dormant Retrovirus Infection?A Mathematical Analysis. Preprints2022, 2022030216. https://doi.org/10.20944/preprints202203.0216.v2
Chen, S. Can Latency-Reversing Drugs Reawaken Dormant Retrovirus Infection?A Mathematical Analysis. Preprints 2022, 2022030216. https://doi.org/10.20944/preprints202203.0216.v2
The technique of using drugs to target latent virus reservoir has been introduced to reawaken the dormant virus so that the immune system can attack it. However, further tests have shown this method to fail in laboratory tests. In this work, the author tries to mathematically analyze whether drugs can be used to reawaken dormant virus reservoirs. The study uses mathematical formulas to differentiate between different relationship types between sets of elements, and then a model of protein reawakening dormant reservoirs is presented. The results show that the amino acid sequences ARG of gag proteins of HTLV1, HTLV2, STLV1 and STLV2 match with their primer binding site GGGGGCTCG in the 3'-to-5' direction, and the amino acid sequences SPR of gag proteins of HIV1, HIV2, SIV and FIV match with their primer binding site GGCGCCCGA in the 3'-to-5' direction. The gag, gag-pol and gag-pro-pol proteins are promising for reawakening dormant retrovirus infection. The author hence believes that the latency-reversing drugs were involved in the process of transcription of cancer, and the genome they reawakened just happened to contain the genome of the retrovirus, which means that it was false reawakening. On the other hand, using proteins of retroviruses to reawaken them is more reliable, just like androgen receptor activates theIGF1Rgene.
Keywords
Retrovirus
Subject
Biology and Life Sciences, Virology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter: S Chen
Commenter's Conflict of Interests: Author