Jahan, S.; Abu Taher, K.; Kaiser, M.S.; Mahmud, M.; Rahman, Md.S.; Hosen, A.S.M.S.; Ra, I.-H. Explainable AI-Based Alzheimer’s Prediction and Management Using Multimodal Data. PLOS ONE 2023, 18, e0294253, doi:10.1371/journal.pone.0294253.
Jahan, S.; Abu Taher, K.; Kaiser, M.S.; Mahmud, M.; Rahman, Md.S.; Hosen, A.S.M.S.; Ra, I.-H. Explainable AI-Based Alzheimer’s Prediction and Management Using Multimodal Data. PLOS ONE 2023, 18, e0294253, doi:10.1371/journal.pone.0294253.
Jahan, S.; Abu Taher, K.; Kaiser, M.S.; Mahmud, M.; Rahman, Md.S.; Hosen, A.S.M.S.; Ra, I.-H. Explainable AI-Based Alzheimer’s Prediction and Management Using Multimodal Data. PLOS ONE 2023, 18, e0294253, doi:10.1371/journal.pone.0294253.
Jahan, S.; Abu Taher, K.; Kaiser, M.S.; Mahmud, M.; Rahman, Md.S.; Hosen, A.S.M.S.; Ra, I.-H. Explainable AI-Based Alzheimer’s Prediction and Management Using Multimodal Data. PLOS ONE 2023, 18, e0294253, doi:10.1371/journal.pone.0294253.
Abstract
According to the World Health Organization (WHO), dementia is the seventh leading reason of death among all illnesses and one of the leading causes of disability among the world’s elderly people. Day by day the number of Alzheimer’s patients is raising. Considering the increasing rate and the dangers, Alzheimer’s disease should be diagnosed carefully. Machine learning is a potential technique for Alzheimer’s diagnosis but general users do not trust machine learning models due to the black-box nature. Even, some of those models do not provide the best performance because of using only neuroimaging data. To solve these issues, this paper proposes a novel explainable Alzheimer’s disease prediction model using a multimodal dataset. This approach performs a data-level fusion using clinical data, Freesurfer MRI segmentation data, and psychological data. For Alzheimer’s disease vs cognitively normal prediction, the random forest classifier provides 100% accuracy. Furthermore, Alzheimer’s disease and non-Alzheimer’s dementia should be classified properly because their symptoms are similar. To the best of our knowledge, we are the first to present a three-class classification on Alzheimer’s disease vs cognitively normal vs non-Alzheimer’s dementia and achieved 99.86% accuracy using an ensemble model. Besides, a novel Alzheimer’s patient management architecture is also proposed in this work..
Keywords
Machine learning; Dementia; Data-level fusion
Subject
Engineering, Control and Systems Engineering
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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