Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

A New Technique to Repair Large Bone Defects

Version 1 : Received: 9 March 2022 / Approved: 9 March 2022 / Online: 9 March 2022 (10:58:33 CET)

How to cite: Tanaka, T.; Komaki, H.; Inagaki, N.; Akiyama, S.; Saito, M. A New Technique to Repair Large Bone Defects. Preprints 2022, 2022030133 (doi: 10.20944/preprints202203.0133.v1). Tanaka, T.; Komaki, H.; Inagaki, N.; Akiyama, S.; Saito, M. A New Technique to Repair Large Bone Defects. Preprints 2022, 2022030133 (doi: 10.20944/preprints202203.0133.v1).

Abstract

It is very difficult to repair large bone defects, especially when they have a complex shape. We have developed a new technique to make a desired copy of rabbit bones. A rabbit distal femur was scanned by computed tomography (CT), and a rectangular-shaped beta-tricalcium phosphate (β-TCP) block with 75% porosity was automatically machined using milling tools into a half-scale copy of the distal femur based on the CT data. The β-TCP block was seeded with bone morphogenetic protein-2 and bone marrow cells obtained from the femur and implanted on the periosteum of the femur. At 10 weeks after implantation, most of the β-TCP block had been replaced by bone and a complete copy of the distal femur was reconstructed. Our findings indicate that this technique will be useful in the clinical setting. We also report the representative clinical results of treatment with β-TCP graft in patients with bone defects since 1989.

Keywords

bone formation; BMP-2; FGF-2; beta-TCP; osteoblast-osteoclast communication

Subject

BIOLOGY, Other

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