Version 1
: Received: 9 March 2022 / Approved: 9 March 2022 / Online: 9 March 2022 (10:58:33 CET)
How to cite:
Tanaka, T.; Komaki, H.; Inagaki, N.; Akiyama, S.; Saito, M. A New Technique to Repair Large Bone Defects. Preprints2022, 2022030133. https://doi.org/10.20944/preprints202203.0133.v1
Tanaka, T.; Komaki, H.; Inagaki, N.; Akiyama, S.; Saito, M. A New Technique to Repair Large Bone Defects. Preprints 2022, 2022030133. https://doi.org/10.20944/preprints202203.0133.v1
Tanaka, T.; Komaki, H.; Inagaki, N.; Akiyama, S.; Saito, M. A New Technique to Repair Large Bone Defects. Preprints2022, 2022030133. https://doi.org/10.20944/preprints202203.0133.v1
APA Style
Tanaka, T., Komaki, H., Inagaki, N., Akiyama, S., & Saito, M. (2022). A New Technique to Repair Large Bone Defects. Preprints. https://doi.org/10.20944/preprints202203.0133.v1
Chicago/Turabian Style
Tanaka, T., Shoshi Akiyama and Mitsuru Saito. 2022 "A New Technique to Repair Large Bone Defects" Preprints. https://doi.org/10.20944/preprints202203.0133.v1
Abstract
It is very difficult to repair large bone defects, especially when they have a complex shape. We have developed a new technique to make a desired copy of rabbit bones. A rabbit distal femur was scanned by computed tomography (CT), and a rectangular-shaped beta-tricalcium phosphate (β-TCP) block with 75% porosity was automatically machined using milling tools into a half-scale copy of the distal femur based on the CT data. The β-TCP block was seeded with bone morphogenetic protein-2 and bone marrow cells obtained from the femur and implanted on the periosteum of the femur. At 10 weeks after implantation, most of the β-TCP block had been replaced by bone and a complete copy of the distal femur was reconstructed. Our findings indicate that this technique will be useful in the clinical setting. We also report the representative clinical results of treatment with β-TCP graft in patients with bone defects since 1989.
Keywords
bone formation; BMP-2; FGF-2; beta-TCP; osteoblast-osteoclast communication
Subject
Biology and Life Sciences, Cell and Developmental Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
