Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Pluripotent Core in Bovine Embryos: A Review

Version 1 : Received: 27 February 2022 / Approved: 1 March 2022 / Online: 1 March 2022 (04:24:34 CET)

A peer-reviewed article of this Preprint also exists.

Aguila, L.; Osycka-Salut, C.; Treulen, F.; Felmer, R. Pluripotent Core in Bovine Embryos: A Review. Animals 2022, 12, 1010. Aguila, L.; Osycka-Salut, C.; Treulen, F.; Felmer, R. Pluripotent Core in Bovine Embryos: A Review. Animals 2022, 12, 1010.

Journal reference: Animals 2022, 12, 1010
DOI: 10.3390/ani12081010

Abstract

Early development in mammals is characterized by the ability of each cell to produce a complete organism plus the extraembryonic, or placental, cells, defined as pluripotency. During subsequent development, pluripotency is lost, and cells begin to differentiate to a particular cell fate. This review summarizes the current knowledge of pluripotency features of bovine embryos cultured in vitro, focusing on the core of pluripotency genes (OCT4, NANOG, SOX2, and CDX2), and main chemical strategies for controlling pluripotent networks during early development. Finally, we will discuss the applicability of manipulating pluripotency during morula to blastocyst transition in cattle species.

Keywords

cattle; in vitro technologies; stem cells; IVF

Subject

LIFE SCIENCES, Biotechnology

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