Review
Version 1
Preserved in Portico This version is not peer-reviewed
Pluripotent Core in Bovine Embryos: A Review
Version 1
: Received: 27 February 2022 / Approved: 1 March 2022 / Online: 1 March 2022 (04:24:34 CET)
A peer-reviewed article of this Preprint also exists.
Aguila, L.; Osycka-Salut, C.; Treulen, F.; Felmer, R. Pluripotent Core in Bovine Embryos: A Review. Animals 2022, 12, 1010. Aguila, L.; Osycka-Salut, C.; Treulen, F.; Felmer, R. Pluripotent Core in Bovine Embryos: A Review. Animals 2022, 12, 1010.
Abstract
Early development in mammals is characterized by the ability of each cell to produce a complete organism plus the extraembryonic, or placental, cells, defined as pluripotency. During subsequent development, pluripotency is lost, and cells begin to differentiate to a particular cell fate. This review summarizes the current knowledge of pluripotency features of bovine embryos cultured in vitro, focusing on the core of pluripotency genes (OCT4, NANOG, SOX2, and CDX2), and main chemical strategies for controlling pluripotent networks during early development. Finally, we will discuss the applicability of manipulating pluripotency during morula to blastocyst transition in cattle species.
Keywords
cattle; in vitro technologies; stem cells; IVF
Subject
Biology and Life Sciences, Biology and Biotechnology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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