Preprint Case Report Version 1 Preserved in Portico This version is not peer-reviewed

The First Case of Granulicatella adiacens Identified from a Resected Heart Valve by Next Generation Sequencing (NGS) in Poland

Version 1 : Received: 31 January 2022 / Approved: 21 February 2022 / Online: 21 February 2022 (10:45:14 CET)

A peer-reviewed article of this Preprint also exists.

Podgórska, A.; Kordybach-Prokopiuk, M.; Jaworska-Wilczyńska, M.; Hoffman, P.; Biernacka, K.; Kuśmierski, K.; Kuthan, R.; Hryniewiecki, T.; Lutyńska, A. The First Case of Granulicatella adiacens Identified from a Resected Heart Valve by Next Generation Sequencing (NGS) in Poland. Pathogens 2022, 11, 295. Podgórska, A.; Kordybach-Prokopiuk, M.; Jaworska-Wilczyńska, M.; Hoffman, P.; Biernacka, K.; Kuśmierski, K.; Kuthan, R.; Hryniewiecki, T.; Lutyńska, A. The First Case of Granulicatella adiacens Identified from a Resected Heart Valve by Next Generation Sequencing (NGS) in Poland. Pathogens 2022, 11, 295.

Journal reference: Pathogens 2022, 11, 295
DOI: 10.3390/pathogens11030295

Abstract

In this report, we describe the course and successful treatment of complicated infective endocarditis (IE). A patient presented with a high-grade irregular fever with chills lasting at least 2 months, dyspnoea, chest pain, fatigue, weight loss, and night sweats during the previous 3 months. Above cardiac congenital disorders, he was found to have Granulicatella adiacens infective aortic valve endocarditis, presumably transmitted from the oral cavity niche. Validated metagenomic 16S rDNA next generation sequencing was used to perform taxonomic identification, allowing for specific adequate antibiotic therapy instead of empiric therapy. This paper highlights the critical role of rapid taxonomic identification of nutritionally variant streptococci crucial and the benefit of proper IE treatment to avoid relapses or fatal complications.

Keywords

Infective endocarditis; Granulicatela adiacens; Nutritionally variant streptococci (NVS); Next-generation sequencing (NGS); Aortic valve

Subject

MEDICINE & PHARMACOLOGY, Cardiology

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